丙型肝炎患者HCV-RNA载量与免疫球蛋白及补体表达水平的相关性

目的 探讨丙型肝炎患者HCV-RNA载量与免疫球蛋白及补体表达水平的相关性.方法 收集2014年6月至2016年5月西安市第九医院收治的丙型肝炎患者132例作为研究对象,对其进行HCV-RNA病毒载量检测,按照检测结果将其分为低载量、中载量以及高载量组,对各组进行免疫球蛋白IgA、IgG、IgM检测以及补体C3、C4检测,分析丙肝患者病毒载量与免疫球蛋白及补体水平的相关性.结果 丙型肝炎患者IgA、IgG、IgM表达量分别为(3.95±0.72) g/L,(19.33±4.64) g/L及(2.93±0.50)g/L],高于健康对照组的表达量(2.13 ±0.51) g/L,(11.25±2.63) g/L及(1.21±0.35) g/L],C3、C4表达量分别为(0.82±0.19) g/L及(0.13±0.08)g/L],低于健康对照组(1.20±0.31)g/L及(0.27±0.11)g/L],差异有统计学意义(P＜0.05).不同病毒载量患者免疫球蛋白及补体表达水平存在差异(P＜0.05).Pearson相关性分析结果显示,HCV-RNA病毒载量与血清免疫球蛋白表达水平呈正相关,与血清补体表达水平呈负相关(P＜0.05).结论 不同病毒载量丙型肝炎患者具有不同的免疫球蛋白及补体表达水平,应当尽量控制HCV-RNA病毒载量,从而减少免疫损伤.

Correlations between viral load and the expression level of immunoglobulins and complements in patients with hepatitis C

Objective To explore the correlations between Hepatitis C viral load (HCV-RNA) and expression level of Immunoglobulin and complements in patients with hepatitis C.Methods 132 patients with hepatitis C accepted in our hospital from Jun.2014 to May 2016 were divided into low load-group,medium-load group and high-load group according to viral load.The expression level of IgA,IgG,IgM,and complements C3 and C4 of each group were tested to anlayze the correlations between viral load and Ig and complements.Results The levels of IgA,IgG and IgM of patients with hepatitis C were (3.95 ± 0.72) g/L,(19.33 ± 4.64) g/L and (2.93 ± 0.50)g/L respectively,which were obviously higher than that of the control group (2.13 ± 0.51) g/L,(11.25 ±2.63)g/L and(1.21 ±0.35)g/L],The levels of C3 and C4 were(0.82 ±0.19)g/L and(0.13 ± 0.08)g/L,which were obviously lower than that of the control group (1.20 ± 0.31)g/L and(0.27 ± 0.11) g/L] with statistically significance (P ＜ 0.05).The levels of Ig and complements of patients with different viral load had statistically difference (P ＜ 0.05).Pearson correlation analysis showed HCV-RNA was positively correlated with Ig and negatively correlated with complements (P ＜ 0.05).Conclusion There are different levels of Ig and complements in patients with different HCV load.Therefore,viral load must be kept under control in order to reduce the injury of immune system.