HIV基因型耐药检测在抗病毒治疗中的应用进展

随着HAART的广泛应用和治疗时间的延长,HIV耐药情况日趋严重.HIV耐药毒株的出现降低了HAART的效果,甚至造成了耐药传播,耐药检测就成为抗病毒过程中重要的监测手段.目前HIV基因型耐药检测已正式应用于临床管理.此文对目前使用的HIV基因型耐药检测方法、原理及分类进行阐述,同时对我国抗HIV一线药物发生耐药后,其耐药检测基因突变位点和耐药结果在临床用药中的指导意义,以及处于不同感染期、特殊人群的HIV/AIDS患者耐药检测指征进行综述.

Application progress of HIV genotypic drug resistance testing in antiretroviral therapy

With the widely application of HAART and prolonged treatment time,HIV drug resistance is becoming more serious.The emergence of HIV drug resistant strains has reduced the effects of HAART,and even caused drug resistant strains' transmission.Therefore,drug resistance testing has become an important monitoring method in the process of antiviral therapy.Currently,HIV genotypic drug resistance testing has been formally applied to clinical management.This article reviews the principle,classification and methods of HIV genotypic drug resistance testing,the clinical values of detected mutation sites and drug resistance results after HIV first-line drug resistance in China,as well as drug resistance testing indications of HIV/AIDS patients in different infection periods and special populations.