淀粉酶、脂肪酶和C反应蛋白联合检测在急性胰腺炎早期诊断中的价值

目的探讨淀粉酶、脂肪酶和C反应蛋白联合检测对急性胰腺炎(AP)的早期诊断价值,以及对病情严重程度的评估价值。方法选取2013年8月至2015年9月该院收治的AP患者60例作为AP组,并选取同期非急性胰腺炎急腹症(NAA)患者32例和健康体检者50例分别作为NAA组和健康组。检测各组血清淀粉酶(AMY)、脂肪酶(LPS)和C反应蛋白(CRP)水平,并进行比较分析。结果 AP组血清AMY、LPS水平分别为(791.9±444.1)、(443.2±119.2)U/L,均高于NAA组与健康组,差异有统计学意义(P0.05)。AP组血清CRP水平为(82.3±37.3)mg/L,与NAA组比较差异无统计学意义(P0.05)。3种指标联合检测用于AP早期诊断的灵敏度、特异度和准确度分别为81.4%、100.0%和90.7%,均高于各指标单独检测,差异有统计学意义(P0.05)。结论血清AMY、LPS和CRP检测有助于急性胰腺炎的早期诊断和病情严重程度的评估。

Value of combined detection of amylase,lipase and C-reactive protein in early diagnosis of acute pancreatitis

Objective To evaluate the early diagnostic value of combined detection of amylase (AMY) ,lipase(LPS) and C-reac-tive protein(CRP) for acute pancreatitis (AP) and its evaluation value on the disease severity .Methods 60 cases of AP in the hospi-tal from August 2013 to September 2015 were selected as the AP group ,meanwhile 32 cases of non-AP acute abdomen(NAA) and 50 cases undergoing healthy physical examination were selected as the NAA group and healthy group respectively .The levels of ser-um CRP ,AMY and LPS in each group were detected and the detection results were performed the comparative analysis .Results The serum AMP and LPS in the AP group were(791 .9 ± 444 .1) and (443 .2 ± 119 .2) U/L respectively ,which were significantly higher than those in the NAA group and healthy group ,the difference was statistically significant (P<0 .05) .The CRP level in the AP group was(82 .3 ± 37 .3)mg/L ,which showed no statistical difference compared with the NAA group (P>0 .05) .The sensitivi-ty ,specificity and accuracy of 3-indicator combined detection for early diagnosis of AP were 81 .4% ,100 .0% and 90 .7% ,which were higher than those in the single indicator detection ,the difference was statistically significant (P<0 .05) .Conclusion The com-bined detection of AMY ,LPS and CRP is conducive to early diagnosis of AP and evaluation of disease severity .