盐酸坦索罗辛治疗前列腺增生伴急性尿潴留的疗效观察

目的 探讨α1肾上腺素能受体阻滞剂盐酸坦索罗辛(tarnsulosin)对良性前列腺增生(BPH)伴急性尿潴留患者的治疗作用.方法 对70例BPH伴急性尿潴留患者采用随机、对照研究,分为治疗组(35例)和对照组(35例).患者均行保留导尿.治疗组加用盐酸坦索力辛0.4 mg,1次/d,连续服用7次,7d后拔除导尿管.结果 拔除导尿管后47.1％ (33/70)的患者能自行排尿.治疗组有效率为68.6％ (24/35),对照组为25.7％(9/35),两组比较差异有统计学意义(P＜0.01).结论 应用盐酸坦索罗辛治疗BPH伴急性尿潴留,提高了早期拔除导尿管后患者自行排尿的成功率,治疗的疗效与前列腺体积大小无关.

Tammlosin in the treatment of benign prostatic hyperplasia with acute urinary retention

Objectives To evaluate the clinical efficacy of α1 adrenoceptor antagonist tamsulosin in the treatment of patients with benign prostatic hyperplasia (BPH) combinded with acute urinary retention.Methods 70 patients with BPH combinded with acute urinary retention were randomly divided into treatment group and control group with 35 in each group.All the patients were treated with indwelling catheter,oral antibiotics and the patients in treatment group were given tamsulosin 0.4 mg once a day for 7 days.The catheter was removed after 7 days.Results After removal of the catheter,47.1％ (33/70) of patients could? urinate? by themselves successfully.The effective rate was 68.6％ (24/35) in the tamsulosin treatment group and 25.7％ (9/35) in the control group,respectively (P ＜ 0.01).Conclusions Treatment with tamsulosin is effective in raising the success rate of voiding without catheter after an episode of acute urinary retention.The efficacy of treatment is not influenced by the volume of prostate.