| P38丝裂原活化蛋白激酶信号转导通路在免疫性疾病中的研究进展 |
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| 引用本文： | 杜乐乐,王婷,王靖宇,王秀梅.P38丝裂原活化蛋白激酶信号转导通路在免疫性疾病中的研究进展[J].国际免疫学杂志,2017,40(5). |
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| 作者姓名： | 杜乐乐 王婷 王靖宇 王秀梅 |
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| 作者单位： | 150086,哈尔滨医科大学附属第二医院口腔内科 |
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| 基金项目： | 哈尔滨市科技局科技创新人才资助项目( 2016RAXYJ094)Project Upported by Scientific and Technological Innovation Personnel of Harbin Science and Technology Bureau |
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| 摘 要： | P38丝裂原活化蛋白激酶(P38 mitogen activated protein kinase,P38MAPK)信号转导通路在机体的免疫应答反应中发挥着重要作用,包括与类风湿性关节炎、原发性干燥综合征、寻常型天疱疮、炎症性肠病、系统性红斑狼疮、骨关节病、银屑病、自身免疫性脑脊髓炎等疾病密切相关.其不仅参与免疫性疾病炎性介质的调节,还参与其发生发展相关基因的调控,因此探讨P38MAPK信号转导通路在免疫性疾病中的作用可为免疫性疾病在临床中的治疗研究提供新的思路.
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| 关 键 词： | P38丝裂原活化蛋白激酶 自身免疫性疾病 激活 |
Research progress of p38 mitogen activated protein kinase signal transduction pathway in immune dis-eases |
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| Du Lele,Wang Ting,Wang Jingyu,Wang Xiumei.Research progress of p38 mitogen activated protein kinase signal transduction pathway in immune dis-eases[J].International Journal of Immunology,2017,40(5). |
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| Authors: | Du Lele Wang Ting Wang Jingyu Wang Xiumei |
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| Abstract: | The p38 mitogen activated protein kinase(p38 MAPK)signal transduction pathway plays an important role in the immune response,including rheumatoid arthritis,primary Sjogren syndrome,pemphigus vul-garis,inflammatory bowel disease,systemic lupus erythematosus,bone joint disease,psoriasis,autoimmune en-cephalomyelitis,and other diseases related. p38MAPK is not only involved in the regulation of inflammatory me-diators of immune diseases,but also associated with the occurrence and development of immune-related disor-ders. Therefore,to study the role of p38MAPK signaling pathway may provide new approaches for the treatment of immune diseases. |
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| Keywords: | P38 mitogen activated protein kinase Autoimmune disease Activation |
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