临床药师在制定免疫球蛋白制剂治疗原发性免疫缺陷性疾病合理用药方案中的作用

对于接受某些药物治疗久治不愈、欲更换免疫球蛋白治疗方案的原发性免疫缺陷性疾病患者进行用药分析,是临床药师在制定和更换治疗方案中的重要职能.由于临床药师既能分析不同免疫球蛋白给药途径的差异,在治疗方案确立中通过分析患者的病史和用药史、不同剂型的药物特性、患者个体差异、药物剂量控制和因人而异的药物免疫耐受程度、患者的经济条件及患者个人喜好等因素来确立合理用药方案,因而临床药师在完善治疗方案、用药监测和更改治疗方案后的用药指导方面具有重要作用.因为临床药师参与治疗并能使治疗效果显著提升,所以免疫球蛋白的个性化治疗是未来抗体治疗的发展趋势,抗体治疗方案的制定过程离不开专业药学人员的参与.

The role of clinical pharmacist in establishing the therapeutic regimen for the patients with primary immune deficiency disease treated with immune globulin

Clinical pharmacists play important role for the determination of treatment regimen for patients with primary immune deficiency diseases by providing pharmaceutical analysis.The role of clinical pharmacists is even critical for these patients receiving long-term immune globulin treatment with no improvement.Selecting a route of administration for immune globulin formulations involves the consideration of many factors,including the patient's medical history,formulation characteristics,individual differences,dosage adjustments,tolerance to drugs,payer formulary and patient preference.Therefore,pharmacists are essential in helping the clinicians to improve the treatment regimen,to monitor patient progress,and to guide the medications during and after the treatment.Personalized treatment plan is the development tendency for antibody treatment in the future,and treatment effect can be improved when clinical pharmacists participate in the complex treatment process.In conclusion,the participation of clinical pharmacists is indispensable in the decision-making and treatment process using immune globulin.