泽桂癃爽胶囊联合克拉霉素缓释片治疗IIIA型前列腺炎的效果观察

目的 探讨泽桂癃爽胶囊联合克拉霉素缓释片在IIIA型前列腺炎治疗中的临床疗效。方法 选择2015年11月至2016年4月于本院泌尿外科门诊就诊的110例IlIA型前列腺炎患者，随机分为泽桂癃爽组和前列康组，前列康组服用克拉霉素缓释片联合前列康治疗4周，然后单用前列康治疗8周，共12周;泽桂癃爽组采用泽桂癃爽胶囊联合克拉霉素缓释片治疗4周，然后单用泽桂癃爽胶囊治疗8周，共12周。观察两组治疗前后前列腺按摩液（EPS）中白细胞计数和NIH-CPSI评分。结果 两组治疗后的第4、8、12周，评估NIH-CPSI评分及其排尿症状评分、生活质量评分、疼痛症状评分及前列腺按摩液中白细胞计数。治疗后均比治疗前有改善(P<0.01或0.05)；治疗组治疗后NIH-CPSI评分与对照组相比差异具有统计学意义(P<0.01)；与治疗第4周末相比，泽桂癃爽组治疗第8、12周后的NIH-CPSI总分及其生活质量评分、排尿症状评分和疼痛症状评分都有明显改善(P<0.05)，但EPS中WBC计数无明显改善((P>0.05)；而治疗第8、12周末的所有指标之间差异均无统计学意义(P>0.05)。而前列康组治疗第4、8、12周末的EPS中WBC计数及NIH-CPSI评分之间差异有统计学意义(P>0.05)。结沦 泽桂癃爽胶囊联合克拉霉素缓释片治疗IIIA型前列腺炎，能降低患者EPS中WBC数目，同时可以有效的改善患者的疼痛及排尿症状，从而提高生活质量，具有较好的临床价值。

Effect of Zeguilongshuang combined with clarithromycin for type IIIA prostatitis

Objectives To investigate the therapeutic efficacy of Zeguilongshuang combined with Clarithromycin for type IIIA prostatitis.Methods One hundred and ten patients with Type IIIA prostatitis were randomly divided into a Zeguilongshuang group,which was given Zeguilongshuang combined with Clarithromycin during the first 4 weeks,followed by Zeguilongshuang alone for 8 weeks,and a Qianliekang group was given Qianliekang combined with Clarithromycin during the first 4 weeks,followed by Zeguilongshuang alone for 8 weeks.NIH-CPSI scores and leukocyte counts in the expressed prostatic secretions of all the patients were analyzed before and after the treatment.Results After 4-week,8-week and 12-week,NIH-CPSI scores and leukocyte counts and the score of pain,voiding symptoms and the quality of life in the expressed prostatic secretions of both the groups were significantly decreased compared with pretreatment(P<0.05 or P<0.01). Compared with the 4-week treatment,total score of NIH-CPSI,and the quality of life , the score of pain and voiding symptoms were revealed to be significantly differents in the Zeguilongshuang group from the 8-week and 12-week treatment,except the leukocyte count in EPS(P<0.05).However,there was no significant difference between the 8-week and 12-week treatment in any of the indexes(P>0.05).While there was no significant difference between the 4-week,8-week and 12-week treatment in any of the indexes in the Qianliekang group(P>0.05).Conclusions Zeguilongshuang combined with Clarithromycin is effective for type IIIA prostatitis,by relieving pain,decreasing the leukocyte count in EPS,voiding symptoms and improving the life quality of the patients.