| T细胞介导的炎症反应在心肌纤维化中的"双刃剑"作用 |
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| 引用本文： | 石亚男,门素珍,孙孟华,刘巍.T细胞介导的炎症反应在心肌纤维化中的"双刃剑"作用[J].国际免疫学杂志,2017,40(5). |
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| 作者姓名： | 石亚男 门素珍 孙孟华 刘巍 |
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| 作者单位： | 150001,哈尔滨医科大学附属第一医院内科危重症科 |
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| 基金项目： | 国家自然科学基金面上项目，哈尔滨医科大学于维汉院士杰出青年基金，黑龙江省教育厅海外学人重点项目(1252HQ013)National Natural Science Foundation of China，Harerbin Medical University Yuwei Han Academician Outstanding Youth Fund，Overseas Scholars Key Projects of Hei-longjiang Provincial Department of Education |
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| 摘 要： | 心肌纤维化涉及到多种复杂的生物学机制.目前,对于免疫介导的心肌纤维化备受关注,而对于心肌损伤时T细胞介导的炎症反应在心肌纤维化中的作用尚存在争议.早期的炎症反应有利于心肌修复,但过度的炎症反应则促进纤维化发生.因此,详尽了解T细胞在心肌纤维化中的作用,有助于通过控制或干预过度的炎症反应来防治心肌纤维化发生,为心脏疾病提供新的治疗方法.
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| 关 键 词： | T淋巴细胞 心肌纤维化 心室重构 炎症 |
The double-edged sword role of T cell-mediated inflammatory reaction in myocardial fibrosis |
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| Shi Ya&#;nan,Men Suzhen,Sun Menghua,Lui Wei.The double-edged sword role of T cell-mediated inflammatory reaction in myocardial fibrosis[J].International Journal of Immunology,2017,40(5). |
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| Authors: | Shi Ya&#;nan Men Suzhen Sun Menghua Lui Wei |
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| Institution: | Shi Ya'nan,Men Suzhen,Sun Menghua,Lui Wei |
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| Abstract: | Myocardial fibrosis involves a variety of complex biological mechanisms. At present,the im-mune-mediated myocardial fibrosis has attracted much attention. In the myocardial injury,T cell-mediated in-flammatory reaction in the role of myocardial fibrosis is still controversial. The early inflammatory reaction is conducive to myocardial repair,while excessive inflammation response can contribute to fibrosis. Therefore,un-derstanding the role of T cells in myocardial fibrosis may help us prevent myocardial fibrosis via controlling or intervening the excessive inflammatory response,and may provide new treatment for heart diseases. |
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| Keywords: | T lymphocytes Myocardial fibrosis Ventricular remodeling Inflammatory |
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