濮阳市不孕患者支原体感染情况及耐药性分析

目的了解濮阳市不孕患者支原体感染及耐药现状,指导临床合理用药。方法对濮阳市500例育龄期女性的阴道分泌物标本进行支原体培养,支原体检测阳性患者分为生育组和不孕组,用液体培养法加固体培养法分离鉴定出解脲脲原体(Uu)和人型支原体(Mh),并测试支原体对12种药物的敏感性。结果对500例育龄期女性阴道分泌物标本进行支原体培养,阳性为220例,总阳性率为44.0%。220例阳性患者中,生育组患者(支原体阳性)60例,占阳性总数的27.3%,不孕组(支原体阳性)160例,占总阳性例数的72.7%,不孕组与生育组构成比比较,差异有统计学意义(P0.05)。不孕组与生育组的Uu感染率分别为71.6%、76.2%,Mh阳性率为11.6%、11.2%;Uu与Mh合并感染率分别为16.6%、12.5%。生育组与不孕组对壮观霉素、强力霉素、美满霉素敏感性较好,敏感率分别为91.8%、92.1%、88.3%,90.9%、90.9%、87.3%。结论不孕患者中Uu感染率较高,且对喹诺酮类和大环内酯类抗菌药物耐药率较高。

Analysis on the infecion status and drug resistant rate of mycoplasma in infertility patients in Puyang city

Objective To observe the infecion status and drug resistant rate of mycoplasma in infertility patients in Puyang city and to guide useing drug rationally.Methods A total of 500 women in reproductive period in Puyang city were recruited in this study,collected their vaginal discharge specimen,then cultured and detected ureaplasma urealyticum(Uu) and mycoplasma hominis(Mh) by liquid culture method and solid culture method.The women with positive results were divided as the pregnancy group and infertility group.The sensitivity rate of mycoplasma to 12 kinds of antibiotic were tested.Results The positive rate of mycoplasma in all the 500 women was 44.0%(220/500),the constituent ratio of pregnancy group(60 cases) was 27.3%,and the constituent ratio of infertility group (160 cases) was 72.7%.The difference was statistically significant between infertility group and pregnancy group(P<0.05).The Uu infection rates in pregnancy group and infertility group were 71.6% and 76.2% respectively,and the Mh infection rates were 11.6%,11.2% respectively.The rates of infecting Uu and Mh at the same time were 16.6% and 12.5%.The mycoplasma in and infertility group the pregnancy group were sensitive to spectinomycin,doxycycline and capminocim,which were 91.8%,92.1%,88.3%;90.9%,90.9%,87.3%.Conclusion The infection rate of Uu is higher than Mh in patients with infertility,which is resistant to quinolone classes and large ring lactone class antibiotic.