维生素D受体基因单核苷酸多态性与结直肠腺瘤相关性的Meta分析

目的 探讨维生索D受体(VDR)基因FokI、BsmI和TaqI位点单核苷酸多态性(SNP)与结直肠腺瘤(CRA)的关系.方法 用Meta分析法研究VDR基因多态性与CRA的关系,计算纳入研究的合并OR值及其95％CI.结果 检索PubMed、Embase和ISI Web of Science数据库,按照既定的纳入标准进行筛选后,最后选择了6项研究.在显性、隐性、等位和相加模型分析中,VDR基因FokI SNP在CRA风险上的合并OR值在4种分析模型中分别为0.97(95％CI:0.83～1.14)、1.06(95％CI:0.84～1.34)、1.00(95％CI:0.89～1.12)和1.04 (95％CI:0.81～1.33),差异均无统计学意义(P均＞0.05).BsmI SNP的合并OR值分别为0.96 (95％CI:0.76～1.20)、0.99(95％CI:0.83～1.19)、0.98(95％CI:0.87～1.12)和0.96(95％CI:0.75～1.23),差异无统计学意义(P均＞0.05).TaqI SNP的合并OR值分别为0.96(95％CI:0.82～1.13)、1.06(95％CI:0.81～1.38)、0.99(95％CI:0.92～1.06)和1.01(95％CI:0.87～1.17),差异无统计学意义(P均＞0.05).结论 VDR基因多态性与CRA之间没有显著联系.

Association between vitamin D receptor gene polymorphism and colorectal adenoma: a Meta-analysis

Objective To investigate the association between colorectal adenoma (CRA) and single nucleotide polymorphisms (SNP) in the 3'regions ofvitamin D receptor (VDR) genes (FokI,BsmI and TaqI).Methods The relation between VDR gene polymorphism and CRA was studied,and odds ratios (OR) and 95％ confidence intervals (95％ CI) were calculated by Meta-analysis.Results The final selection enrolled 6 studies after searching the databases of PubMed,Embase and ISI Web of Science.For FokI SNP,the pooled ORs were 0.97 (95％CI:0.83-1.14),1.06 (95％CI:0.84-1.34),1.00 (95％CI:0.89-1.12) and 1.04 (95％CI:0.81-1.33) in dominant,recessive,allelic and additive models respectively,of which the differences had no statistical significance (Pall ＞0.05).For BsmI SNP,ORs were 0.96 (95％CI:0.76-1.20),0.99 (95％CI:0.83-1.19),0.98 (95％CI:0.87-1.12) and 0.96 (95％CI:0.75-1.23),of which the differences had no statistical significance (P all ＞0.05).And for TaqI SNP,the ORs were 0.96 (95％CI:0.82-1.13),1,06 (95％CI:0.81-1.38),0.99 (95％CI:0.92-1.06) and 1.01 (95％CI:0.87-1.17),of which the differences had no statistical significance (P all ＞0.05).Conclusions There is no obvious association between CRA and VDR gene polymorphism.