~(18)F-FDG PET/CT与血清CEA对进展期胃癌新辅助化疗联合手术治疗后转移或复发监测价值

目的探讨18F-FDG正电子发射断层成像术(PET/CT)显像与血清癌胚抗原(CEA)水平检测对进展期胃癌新辅助化疗联合手术治疗后转移或复发的诊断价值。方法选择96例进展期胃癌且行新辅助化疗联合手术治疗患者为研究对象,对其进行2年以上随访,进行PET/CT显像与血清CEA水平检测,评价二者对患者治疗后复发或转移的诊断价值,并进行统计学分析。结果纳入研究的96例患者,复发、转移47例,PET/CT联合CEA对复发或转移阳性确诊率及阴性确诊率显著高于单纯PET/CT、血清CEA,差异有统计学意义(P0.05);PET/CT联合CEA对复发或转移诊断敏感度、特异度及准确度著高于单纯PET/CT、血清CEA,差异有统计学意义(P0.05)。结论对进展期胃癌新辅助化疗合并手术治疗后采用18 F-FDG PET/CT显像与血清CEA水平检测联合监测,有助于提高化疗后转移或复发诊断。

The value of recurrence or metastasis of 18F-FDG PET/CT and serumCEA in patients with advanced gastric cancer after neoadjuvant chemotherapy combined with surgical treatment

Objective To investigate the value of 18F-FDG PET/CT and serum CEA in patients with advanced gastric cancer after neoadjuvant chemotherapy combined with surgical treatment.Methods 96 cases of patients with advanced gastric cancer who underwent neoadjuvant chemotherapy combined with surgery as the research object,after more than 2 years of follow-up,PET/CT imaging and serum CEA levels were detected,and the diagnostic value of recurrence or metastasis of the two groups were evaluated and analyzed.Results Of the 96 patients enrolled in the study,there were 47 cases of recurrence and metastasis,PET/CT combined with CEA for recurrence or metastasis positive diagnosis rate and negative diagnosis rate was significantly higher than that of pure PET/CT and serum CEA,the difference was statistically significant(P<0.05).The sensitivity,specificity and accuracy of PET/CT combined with CEA in the diagnosis of recurrence or metastasis were higher than that of PET/CT and serum CEA,the difference was statistically significant(P<0.05).Conclusion The combined monitoring of 18F-FDG PET/CT imaging and serum CEA level in patients with advanced gastric cancer after neoadjuvant chemotherapy combined with surgical treatment is helpful to improve the diagnosis of metastasis or recurrence.