大电导钙激活钾通道与心血管保护

背景 大电导钙激活钾通道(large conductance Ca2+-activated K+ channels,BKCa)可能是各类心脏疾病的重要治疗靶点. 目的 主要阐述如何通过调节心肌及血管平滑肌的BKCa通道而发挥保护心肌作用及其相关机制. 内容 在心肌细胞的线粒体上,BKCa通道能够有效地调节线粒体的活性氧、Ca2+和呼吸作用.在血管平滑肌细胞,BKCa通道能调节血管紧张度,促进血管扩张. 趋向 BKCa通道在心肌缺血/再灌注(ischemia/reperfusion,I/R)损伤中有着重要的作用,包括改善心肌功能和减少梗死面积.

Large-conductance Ca2+-activated K+ channels and cardiovascular protection

Background Large-conductance Ca2+-activated K+ channels (BKCa) may be important targets for therapeutic interventions in a variety of cardiac conditions.Objective This mini-review focuses on the modulation of cardiomyocyte BKCa channels for cardioprotection and briefly address associated potential therapeutic benefits in the coronary circulation.Content In cardiomyocytes,BKCa channels are localized to mitochondria where they beneficially modulate reactive oxygen species,mitochondrial Ca2+,and respiration.In vascular smooth muscle cells,BKCa channels regulate vascular tone and promote vasodilation.Trend Activation of BKCa channels has demonstrated significant cardioprotection following ischemic injury,including improving myocardial function and reducing infarct size.