血清MFG-E8水平与颈动脉粥样硬化程度的相关性分析

目的探讨不同程度颈动脉粥样硬化(CAS)患者血清乳脂肪球表皮生长因子8(MFG-E8)水平变化,及其与血糖、血脂和炎症因子的相关性。方法选取2015年10月至2017年2月该院确诊为颈动脉粥样硬化的患者120例,分为对照组、增厚组和斑块组,每组各40例,比较3组血糖、血脂、血清MFG-E8和其他炎症因子水平,并分析血清MFG-E8与其他指标的相关性。结果斑块组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs-CRP)水平均明显高于增厚组和对照组,差异有统计学意义(P0.05);斑块组MFG-E8、白细胞介素-10(IL-10)水平均明显低于增厚组和对照组,差异有统计学意义(P0.05);3组间空腹血糖(FPG)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)水平差异无统计学意义(P0.05)。血清MFG-E8与颈动脉内膜中层厚度、FPG、TC、LDL-C、TNF-α和hs-CRP呈负相关(P0.05),与TG和IL-10呈正相关(P0.05),与HDL-C无相关性(r=0.105,P=0.255)。结论血清MFG-E8可作为评估CAS病情严重程度的新指标,值得临床推广应用。

Correlation analysis between serum MFG-E8 level and carotid atherosclerosis

Objective To investigate the changes of serum milk fat globule epidermal growth factor 8(MFG-E8) levels in pa-tients with carotid atherosclerosis(CAS) ,and the correlation analysis between MFG-E8 and blood glucose ,blood lipid and inflam-matory factors .Methods From October 2015 to February 2017 ,120 patients with carotid atherosclerosis were selected and divided into control group ,thickening group and plaque group ,40 cases in each group .The levels of blood glucose ,blood lipid ,serum MFG-E8 and other inflammatory factors of the three groups were compared ,and the correlation between serum MFG-E8 and other indica-tors .was analyzed .Results The levels of total cholesterol(TC) ,low-density lipoprotein cholesterol(LDL-C) ,tumor necrosis factor alpha(TNF-α) ,and high sensitive C reactive protein (hs-CRP) in plaque group were significantly higher than those in thickening group and control group ,the difference was statistically significant(P<0 .05);the levels of MFG-E8 and interleukin-10(IL-10) in plaque group were significantly lower than those in thickening group and control group ,the difference was statistically significant (P<0 .05);there was no significant difference in the levels of fasting blood glucose (FPG) ,triglyceride(TG) and high-density lipo-protein cholesterol(HDL-C) between the three groups(P>0 .05) .Serum MFG-E8 was negatively correlated with carotid intima-media thickness ,FPG ,TC ,LDL-C ,TNF-αand hs-CRP(P<0 .05)and positively correlated with TG and IL-10(P<0 .05) ,and there was no correlation between serum MFG-E8 and HDL-C(r=0 .105 ,P=0 .255) .Conclusion Serum MFG-E8 can be used as a new index to assess the severity of CAS and it is worthy of clinical application .