乳山市两所医院鲍曼不动杆菌耐药性及流行性分析

目的分析乳山市两所医院鲍曼不动杆菌的耐药性及流行特点。方法收集乳山市人民医院、乳山市中医院2015年1-12月临床分离鲍曼不动杆菌,进行药敏试验,选取50株鲍曼不动杆菌采用脉冲场凝胶电泳分析菌株同源性。结果共收集鲍曼不动杆菌158株,其中乳山市人民医院108株,乳山市中医院50株。标本来源以痰液(59.9%)为主,分布科室以呼吸科(39.8%)和ICU(25.3%)为主。药敏结果显示,所检测菌株对氨曲南、氨苄西林、头孢西丁100.0%耐药,对多黏菌素B、替加环素均敏感。50株鲍曼不动杆菌可分为A~E共5种型别,其中A型又分为A1、A2、A3等3个亚型,为主要流行型别。结论乳山市两所医院鲍曼不动杆菌耐药问题较严峻,主要存在于呼吸科、ICU等科室,以引起呼吸道感染为主,在两所医院不同科室间存在播散流行。

Analysis on resistance and epidemic trend of Acinetobacter baumannii in two hospitals of Rushan City

Objective To analyze drug resistance and epidemic features of Acinetobacter baumannii in two hospitals of Rushan city .Methods Acinetobacter baumannii strains were collected from Rushan People′s Hospital and Chinese Medicine Hospital of Rushan in 2015 .Antimicrobial susceptibility test was carried out by Kirby-Bauer(K-B) method .Homology analysis were conducted by pulsed-field gel electrophoresis(PFGE) in 50 Acinetobacter baumannii strains .Results There were 158 Acinetobacter baumannii strains were isolated ,108 strains were from Rushan People′s Hospital ,50 strains were from Chinese Medicine Hospital of Rushan . 59 .9% strains was from sputum specimens .The most strains were from Respiratory department (39 .8% ) and ICU (25 .3% ) .All strains were resistant to aztreonam ,ampicillin and cefoxitin ,but sensitive to polymyxin B and tigecycline .50 strains could be divided into five types(A -E) .A typewas the predominant type ,including A1 ,A2 ,A3 three subtypes .Conclusion The resistance of Acine-tobacter baumannii was serious in the two hospitals in Rushan city .It mainly cause respiratory infections ,and could spread among different departments .The most strains were from Respiratory Department and ICU .