树突状细胞在慢性阻塞性肺疾病中的作用

树突状细胞(dendritic cells,DCs)作为机体内最重要的一种抗原提呈细胞,在慢性阻塞性疾病(chronic obstructive pulmonary disease,COPD)炎症的发生发展过程中具有重要作用.长期烟雾刺激,会导致肺部DCs亚群失衡,DCs向肺部炎症部位募集,通过与CD4+T细胞的相互作用,导致Th17/调节性T细胞免疫失衡,介导COPD细胞免疫过程.此外,COPD肺组织中肺泡弹性蛋白降解形成的具有抗原活性的弹性蛋白肽与肺部DCs的免疫作用,在COPD疾病的持续进展过程中具有十分重要的作用.

The role of dendritic cells in chronic obstructive pulmonary disease

Dendritic cells (DCs) are the most important professional antigen presenting cells which play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD).Cigarette smoking could result in the unbalance of DCs subjects and promote DCs accumulating to inflammatory sites in lungs.The regulatory and p01arized effectors of CD4 + T cells could be induced and regulated by DCs,which may lead to the unbalance of Th17/Treg cells.Thus,DCs play a key role in the cellular immuce response in COPD.Elastin peptides which possess characteristic of antigen activity,are the products of lung elastin degradation in COPD.The immunity effects between elastin peptides and DCs are closely related to the progression of chronic inflammation in COPD.