2型糖尿病患者血清抵抗素与尿白蛋白排泄率的关系

目的 检测不同尿白蛋白排泄率（UAER）的2型糖尿病患者血清抵抗素（RESISTIN）水平，并探讨尿白蛋白排泄率与抵抗素之间的关系。方法 酶联免疫检测法（EHSA）测定60例研究对象空腹血清抵抗素水平。其中2型糖尿病伴微量白蛋白尿组20例；2型糖尿病UAER．正常组20例，健康对照组20例。结果 2型糖尿病伴微量白蛋白尿组的血清抵抗素浓度高于2型糖尿病UAER正常组（P〈0．05）；且2型糖尿病UAER正常者组的抵抗素水平又高于健康对照组（P〈0．05）；其值分别为1．80（1．55～2．45）；1．57（1．29～1．87）；1．29（1．07～1．47）．结论 2型糖尿病及其微量白蛋白尿的形成可能与抵抗素相关。

Relationship between resistin and UAER in patients with type 2 diabetes mellitus

Objective] To investigate the level of serum resistin in the subject suffering from Type2 diabetes with different UAER and control groups.Then we try to find out the correlation among them.Method] 40 patients with different quantity of Albuminuria(20 of Type2 diabetes were with micro-UAER,20 of Type2 diabetes were with normal-UAER)were selected as study groups,20 healthy persons were selected as control group.The levels of resistin were measured after an overnight fasting by competitive ELISA.Result] The fasting serum level of resistin in Type2 diabetes with micro-UAER were higher than that of Type2 diabetes with normal-UAER(P <0.05)and control group(P <0.05);the figure were 1.80(1.55-2.45);1.57(1.29-1.87);1.29(1.07-1.47)repectively.Conclusion] Resistin may play a role in the form of Albuminuria of Type2 diabetes.