膀胱原发性印戒细胞癌伴发前列腺腺癌1例报告及文献复习

目的:探讨膀胱原发性印戒细胞癌(primary signet ring cell carcinoma of the bladder.PSRCC)伴前列腺癌的临床特征及诊治方法。方法:总结1例膀胱PSRCC伴前列腺癌患者的资料,检索Pubmed、CBM数据库相关文献并复习。结果:膀胱镜检病理示膀胱印戒细胞癌。血PS A:12.73 ng/ml,FPSA:0.737 ng/ml,FPSA/PSA:0.06。前列腺穿刺活检示前列腺腺癌,Gleason评分3+3。行经尿道膀胱肿瘤切除术(TURBT)术和最大限度雄激素阻断治疗,术后1 6个月膀胱癌复发。结论:膀胱PSRCC临床少见,浸润性强,进展快,诊断主要依靠病理和免疫组织化学检查,对于膀胱PSRCC伴发前列腺癌首选根治性膀胱前列腺切除术治疗,预后差。

Coexistence of Primary Signet ring Cell Carcinoma of Bladder and Adeno-carcinoma of Prostate: Report of 1 Case and Review of the Literature

Objective：To discuss the clinical and pathological features of the coexistence of primary signet ring cell carcinoma（PSRCC） of bladder and adcnocarcinoma of prostate. Methods：One case of coexistence of PSRCC of bladder and adenocarcinoma of prostate was reported. We searched and reviewed databases （Pubmed, CBM disc） for the literature. Results：Biopsy of the bladder mueosa was performed. The pathology showed PSRCC of bladder; the serum PSA was 12.73 ng/ml,the serum FPSA was 0. 737 ng/ml, the FPSA/PSA was 0.06, prostate biopsy showed prostate adenocarcinoma, Gleason score was 6. The patient received transurethral resection of bladder tumor （TUR Bt） and maximal androgen blockade therapy. The patient recurred 16 months after operation. Conelusions：PSRCC of bladder was a rare aggressive disease with no specific clinical feature in most cases. Diagnosis of PSRCC of bladder should be confirmed with histological features and immunohistochemistry. Radical cystoprostatectomy is one of the optimal approaches for treatment of coexistence of PSRCC of bladder and adenocarcinoma of prostate. The prognosis of PSRCC of bladder is poor.