18F-FDG PET脑显像对小儿原发性癫痫病灶定位诊断的研究

目的：评价18F－FDG PET脑显像对小儿原发性癫痫定性和病灶定位的诊断价值。方法：对32例CT或MRI检查正常的小儿原发性癫痫患者进行18F－FDG PET脑显像，29例发作间期，3例发作期显像，并同步进行EEG检查，对两种检查结果进行比较。结果：发作间期29例患者PET显像25例异常，发作期3例患者均异常，总阳性率88％，EEG检查异常的20例患儿中与PET异常部位完全或基本符合率为70％，结论：18F－FDG PET脑显像是诊断小儿原发性癫痫病灶的有效方法，灵敏度优于EEG，但PET所示异常范围并非都是致痫灶，尚需与EEG结合分析，方能提高其定位准确性。

Study on localization diagnosis with 18F-FDG PET imaging in children with primary epilepsia

Objective To evaluate the diagnostic value of 18 F-FDG PET imaging in localizing epileptic foci in children with primary epilepsia. Methods 18 F-FDG PET brain imaging was performed in 32 children with primary epilepsia and normal CT or MRI. 29 were interictal and 3 were ictal. Electroencephalogram (EEG) was recored simultaneously. All results were compared with each other. Results 25 of 29 interictal patients had abnormalities on PET imaging, all 3 ictal patients had abnormal PET. The total positive rate was 87.5%. The epileptic foci localized by EEG(20 abnormalities) was 70% in concordance with those by PET. Conclusions 18 F-FDG PET brain imaging is a sensitive and effective method for epileptic foci localization in children. It may have some advantages over EEG. However, abnormal PET areas may not be epileptic foci. A combination of PET and EEG will improve the positive rate and accuracy for localization.