| 大麻酚类受体拮抗剂SR141716A减少乙醇蒸气室中大鼠的自发反应性乙醇自身给药行为(英文) |
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| 引用本文： | Feinando RODRIGUEZ DE FONSECA,Amanda J ROBERTS,Ainhoa BILBAO,George F KOOB,Miguel NAVARRO. 大麻酚类受体拮抗剂SR141716A减少乙醇蒸气室中大鼠的自发反应性乙醇自身给药行为(英文)[J]. Acta pharmacologica Sinica, 1999, 0(12) |
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| 作者姓名： | Feinando RODRIGUEZ DE FONSECA Amanda J ROBERTS Ainhoa BILBAO George F KOOB Miguel NAVARRO |
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| 作者单位： | Instituto Complutense de Drogodependencias，Departamenta de Psicobiologia，Facultad de Psicologia，Universidad Complutense de Madrid，28223-Madrid，Spain，Department of Neuropharmacology，The Scripps Research Institute，La Jolla CA 92037，USA，Instituto Complutense de Drogodependencias，Departamenta de Psicobiologia，Facultad de Psicologia，Universidad Complutense de Madrid，28223-Madrid，Spain，Department of Neuropharmacology，The Scripps Research Institute，La Jolla CA 92037，USA，Instituto Complutense de Drogodependencias，Departamenta de Psicobiologia，Facultad de Psicologia，Universidad Complutense de Madrid，28223-Madrid，Spain |
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| 基金项目： | DGICYT PM 96/0047,Comunidad de Madrid and Plan Nacional Sobre Drogas (MN,FRF)，National Institutes of Health grants AA 06420，AA 08459 from the National Institute on Alcohol Abuse and Alcoholism (GFK and AJR) |
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| 摘 要： | AIM: To study the potential role of dependence statuson CB_1-mediated blockade of ethanol self-administra-tion. METHODS: We examined the effects of thecannabinoid antagonist SR141716A (0, 0.03, 0.3,and 3 mg/kg) on pperant ethanol (10 ％ v/v) self-administration in male Wistar rats that were madeethanol-dependent by chronic (14 d ) exposure toethanol vapor-chambers or exposed to air in identicalvapor chambers.RESULTS: Dependent animalsresponded more for ethanol than did air controlnondependent tats. The acute administration of a 3mg/kg dose of SR141716A almost suppressed ethanolself-administration ouly in ethanol dependent animals.
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| 关 键 词： | 乙醇 自身给药 大麻酚类受体 SR141716A |
Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers |
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| Feinando RODRIGUEZ DE FONSECA,Amanda J ROBERTS,Ainhoa BILBAO,George F KOOB,Miguel NAVARRO. Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers[J]. Acta pharmacologica Sinica, 1999, 0(12) |
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| Authors: | Feinando RODRIGUEZ DE FONSECA Amanda J ROBERTS Ainhoa BILBAO George F KOOB Miguel NAVARRO |
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| Abstract: | ABM: To study the potential role of dependence status on CB1-mediated blockade of ethanol self-administration. METHODS: We examined the effects of the cannabinoid antagonist SR141716A (0, 0.03, 0.3, and 3 mg/kg) on operant ethanol (10 % v/v) self-administration in male Wistar rats that were made ethanol-dependent by chronic (14 d) exposure to ethanol vapor-chambers or exposed to air in identical vapor chambers. RESULTS: Dependent animals responded more for ethanol than did air control nondependent rats. The acute administration of a 3 mg/kg dose of SR141716A almost suppressed ethanol self-administration only in ethanol dependent animals. However, operant responses for food were not affected by the administration of SR141716A. CONCLUSION: These results further support that cannabinoid CB1 receptor blockade may have a potential utility for the treatment of alcoholism. |
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| Keywords: | ethanol self administration cannabinoid rcceptors SR141716A |
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