阻塞性睡眠呼吸暂停低通气综合症与高血压关系的分析

目的：探索伴有高血压的阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的睡眠呼吸障碍特点。方法：诊断为OSAHS的85例患者中，随机被分为伴有高血压组（50例）和不伴有高血压组（对照组，35例），对两组相关指标进行分析。结果：较之对照组．高血压组睡眠呼吸暂停低通气指数（AHI）显著升高（P〈0．01）；夜间平均脉搏氧饱和度（SpO2）和最低SpO2显著下降（P〈0．05）；快动跟睡眠期的阻塞性呼吸暂停指数（OAI）显著升高（P〈0．01）。方差检验揭示体重指数（BMI）是引起两组间AHI差异的显著因素（F=22．12，P〈0．01）。Logistic分析揭示OSAHS患者高血压的危险因素是AHI（β=6．828，OR=1．017，P〈0．01）、年龄（p=8．590，OR=1．048，P〈0．01）、BMI（β=4．467，OR=1．118，P〈0．05）。结论：伴有OSAHS的高血压患者的睡眠呼吸障碍程度更重，夜间低氧血症更严重。

Relationship between obstructive sleep apnea syndrome and hypertension

Objective： To explore the character of obstructive sleep apnea--hypopnea syndrome （OSAHS） combined hypertension. Methods： The 85 OSAHS patients were randomly divided into OSAHS combined hypertension group （hypertension group, 50 cases） and control group （no-combined hypertension group, 35 cases）. The correlated index was analyzed between two groups. Results： Compared with control group, the apnea hyponea index （AHI） significantly increased （P〈0.01） ; the average pulse oxygen satulation （SpO2） and lowest SpO2 significantly decreased （P〈 0.05） ; the obstructive apnea index （OAI） of rapid eye movement sleep （REM） significantly increased （P〈0.01） in hypertension group. Variance test show that BMI was significant factor for significant difference of AHI in two groups （F=22. 12, P〈0. 01）. Logistic regression analysis show that risk factor of hypertension was AHI （β=6. 828, OR =1.017, P〈.0.01）, age （β=8.590, OR=1.048, P〈0.01）, BMI （β=4.467, OR=1.118, P〈0.05）. Conclusion： The sleep--disordered breathing and nocturnal hyoxemia are more severity in OSAHS patient with hypertension.