肺炎患儿血小板参数的变化及其临床意义

目的观察细菌、病毒、支原体所致轻、重症肺炎患儿血小板参数的变化并分析其临床意义。方法回顾性研究2010年11月—2012年3月我科收治的180例细菌性、病毒性及支原体肺炎(各60例,其中重症肺炎62例,轻症肺炎118例)急性期和恢复期血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、血小板宽度(PDW)的变化,并与50例对照组进行比较。结果三组肺炎患儿血小板参数均高于对照组,细菌性肺炎组患儿血小板参数明显高于病毒性肺炎组和支原体肺炎组(P<0.01);急性期重症肺炎患儿血小板参数明显高于轻症肺炎者(P<0.01),且两者均明显高于对照组;恢复期重症及轻症肺炎患儿血小板参数均明显降低,与对照组无差异。结论肺炎患儿血小板数量及功能状态通常异常,以细菌性肺炎更易于发生;血小板参数的变化可作为肺炎严重程度及病情变化的一项参考指标。

Clinical significance and changes of platelet parameter in child patients with pneumonia

Objective To investigate the changes and analyze the clinical significance of platelet parameter in child patients with pneumonia caused by microbe,virus and mycoplasma.Methods The medical records of 180 child patients(including 62 cases of severe pneumonia,118 cases of mild pneumonia) with microbial,viral and mycoplasma pneumonia from December 2010 to March 2011 were retrospectively reviewed(including 60 cases of microbial pneumonia,60 cases of viral pneumonia and 60 cases of mycoplasma pneumonia).The changes of platelet parameters such as platelet count(PLT),platelet hematocrit(PCT),mean platelet volume(MPV) and platelet distribution width(PDW) in acute stage and in convalescence stage of patients with pneumonia were observed and compared with 50 cases normal control group.Results The platelet parameters of microbial pneumonia group,viral pneumonia group and mycoplasma pneumonia group were significantly higher than those of normal control group(P<0.01).The platelet parameters of microbial pneumonia group were significantly higher than those of viral pneumonia group and mycoplasma pneumonia group(P<0.05).The platelet parameters of severe pneumonia group were significantly higher than those of mild pneumonia group in acute stage(P<0.05),but they were significantly higher than those of normal control group.The platelet parameters of both severe pneumonia group and mild pneumonia group in convalescence stage were significantly decreased and there were no significant difference from normal control group.Conclusion The abnormality of the amount and function of platelet is the common pathological process of children pneumonia,and it is more prone to microbial pneumonia,thus the changes of platelet parameter maybe reference marker for predicting the patients with pneumonia and accessing the severity.