Impact of convective transport on dialyzer clearance |
| |
Authors: | M Galach A Ciechanowska S Sabalińska J Waniewski J Wójcicki A Weryńskis |
| |
Institution: | (1) Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, ul. Trojdena 4, 02-109 Warsaw, Poland Fax +4822 6582872 e-mail: magda@ibib.waw.pl, PL |
| |
Abstract: | The results of predictions of three mathematical models used to describe the impact of convective flow on dialyzer clearance
are presented. These models are based on the ordinary differential equations, which describe changes of solute concentration
and solute and fluid flows along the module length. One of the models takes into consideration the existence of the boundary
layers on both sides of the membrane wall, by including in the equations two parameters k
B
and k
D
, which describe mass transport coefficients in blood and dialysate, respectively. In the second model, the boundary layers
are included in one lumped membrane permeability parameter. The diffusive membrane permeability was calculated from pure diffusive
clearance, which was taken from experimental results. In the third model, a linear dependence of transmittance coefficient
and ultrafiltration flow was proposed. The theoretical results were compared with data obtained in experiments carried out
in vitro with four types of high-flux hollow-fiber dialyzers. The comparisons demonstrate that the first two models are of
similar accuracy and the third model is not suitable for small solutes.
Received: June 17, 2002 / Accepted: October 16, 2002
Acknowledgments This study was supported by Fresenius Medical Care Deutschland GmbH. The authors thank Dr. Cecile Legallais, University of
Compiegne, France, for help with the references.
Correspondence to:M. Galach |
| |
Keywords: | Convective transport Dialysis Transmittance coefficient Mathematical model |
本文献已被 SpringerLink 等数据库收录! |
|