| 英连金化浊解毒方对胃癌前病变大鼠CD44V6表达的影响 |
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| 引用本文： | 刘启泉,王维,王志坤,靳凌瑜,苏芳,张晓利.英连金化浊解毒方对胃癌前病变大鼠CD44V6表达的影响[J].辽宁中医杂志,2011(6):1227-1229. |
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| 作者姓名： | 刘启泉 王维 王志坤 靳凌瑜 苏芳 张晓利 |
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| 作者单位： | 河北省中医院消化内科;河北医科大学; |
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| 基金项目： | 国家中医药管理局十一五重点研究慢性胃炎研究室专项课题(ZD200830-10) |
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| 摘 要： | 目的:观察英连金化浊解毒方对慢性萎缩性胃炎伴中度IM或轻度Dys大鼠的CD44V6基因蛋白表达的影响。方法:将120只大鼠随机分为空白组、模型组、大、中、小剂量组及干预组。采用N-甲基-N-硝基N-亚硝基胍配合饥饱失常诱导造模。造模后分组治疗,24周后处死全部实验大鼠并通过TUNEL细胞凋亡检测法对CD44V6指标进行检测。结果:与空白组相比,模型组CD44V6表达率明显增高,差异有统计学意义(P<0.05),英连金化浊解毒方大、中、小剂量组CD44V6表达率同模型组两两比较均降低,差异均具有统计学意义(P<0.05)。结论:英连金化浊解毒方(大、中、小剂量组)能够明显改善胃黏膜组织病理状况,降低Cd44v6基因蛋白表达。
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| 关 键 词： | 胃癌前病变 CD44V6 英连金化浊解毒方 实验研究 |
YingLianjin Huazhuo Detoxification Fang Impact on the CD44V6 for in PLGC's Rats |
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| LIU Qi-quan,WANG Wei,WANG Zhi-kun,ZHANG Xiao-li,JIN Ling-yu,SU Fang.YingLianjin Huazhuo Detoxification Fang Impact on the CD44V6 for in PLGC's Rats[J].Liaoning Journal of Traditional Chinese Medicine,2011(6):1227-1229. |
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| Authors: | LIU Qi-quan WANG Wei WANG Zhi-kun ZHANG Xiao-li JIN Ling-yu SU Fang |
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| Institution: | LIU Qi-quan1,WANG Wei2,WANG Zhi-kun1,ZHANG Xiao-li1,JIN Ling-yu2,SU Fang2(1.Digestive System Department of Chinese Medicine Hospital in Heibei Province,Shijiazhang 050011,Hebei,China,2.Hebei Medical University,China) |
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| Abstract: | Objective:To observe the YingLianjin Huazhuo detoxification Fang impact on the CD44V6 for in PLGC's rats.Methods:120 rats were randomly divided into blank group,model group,large,medium and small dose group and intervention group.By N-methyl-N-nitro-N-nitrosoguanidine induced irregular diet with modeling.24 weeks later all rats were TUNEL detection of apoptosis and CD44V6 Markers.Results:Compared with the control group,the expression of CD44V6 in model group was increased significantly(P<0.05),YingLianjin H... |
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| Keywords: | PLGC CD44V6 Ying Lianjin Huazhuo detoxification Fang Experimental study |
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