肺癌CT伪彩成像肿瘤红色色彩程度与Ki-67蛋白表达关系初步研究

[摘要] 目的 探讨肺癌16层螺旋CT伪彩成像肿瘤红色色彩程度与其Ki-67蛋白表达的关系。方法 25例肺癌行16层螺旋CT增强扫描及肿瘤病灶VR伪彩成像，对每个肿瘤病灶进行免疫组化Ki-67蛋白表达检测。用肿瘤VR伪彩成像红色色彩程度代表肿瘤强化状况，分析肺癌病灶VR伪彩成像红色色彩程度与肿瘤Ki-67蛋白表达关系。结果 VR伪彩成像重度红色色彩肺癌5例，中度红色色彩肺癌8例，轻度红色色彩肺癌9例，无红色色彩肺癌3例。13例重、中度红色色彩肺癌强化增加CT值为26.32±9.17Hu，肿瘤Ki-67蛋白表达阳性率为69.23%。12例轻及无红色色彩肺癌强化增加CT值为10.87±4.257Hu，肿瘤Ki-67蛋白表达阳性率为33.33%。重、中度色彩组与轻或无色彩组肺癌Ki-67蛋白表达比较差异有显著性。结论 肺癌CT伪彩成像红色色彩程度与肿瘤Ki-67蛋白表达有一定相关性,可初步反映其Ki－67表达状况。

The relationship between the extent of red color on color CT image and protein expression of Ki-67 in the lung carcinoma

Objective To discuss the relationship between the extent of red color on color CT image and protein expression of Ki-67 in lung carcinoma.Methods The enhanced CT scan was performed by using 16-slices spiral CT in 25 cases with pulmonary carcinoma and proved by pathology.Color VR of tumor lesions of pulmonary carcinoma were performed.Protein expression of Ki-67 in tumor lesion of pulmonary carcinoma was performed by immunohistochemistry in 25 cases.The relationship between the extent of red color on color VR...