磷酸羟基哌喹治疗矽肺的研究

磷酸羟基哌喹是我校研制的一种抗疟新药。经对大鼠实验性矽肺治疗表明,按100mg/kg体重每周两次的剂量,于病程早期或晚期投药,均有显著的疗效。试治663例矽肺病人结果表明,患者服药后,经线胸片复查,其中153例(占23.07％)显示好转,仅6.49％的病例仍有进展,其余均为稳定。研究证明,本药能减轻病痛,阻止或延缓病程进展,可作为较好的矽肺治疗药物以推广使用。

STUDIES ON THE TREATMENT OF SILICOSIS WITH HYDROXYPiPERAQUINE PHOSPHATE

We have synthesized Hydroxypiperaquine Phosphate (HPQP) as a new antimalarial drug in 1971. Studies have shown that the drug has markedly therapeutic effects on experimental silicosis after administration to rats 100mg/kg by oral twice per week and the treatment was performed either in the earlier or later course of silicosis. We tried to treat 663 cases for silicosis with HPQP. Patients took cure up to two years. As a result of therapeutic effect examining by X-ray photograph, it revealed that 153 cases of them were marked improved, a few of cases (about 6.49%) were still in progress, and the remainders were stable as before.This study proved that HPQP can alleviate patients' suffering, prevent or retard the progress of the disease. We, there-fore, recommed the drug to be the choice of good therapeutic medicine for silicosis.