Sex differences in mouse platelet aggregation |
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| Authors: | A P Torres Duarte P Ramwell A Myers |
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| Institution: | 1. Department of Vascular and Endovascular Surgery, Heinrich-Heine-University University Medical Center, Moorenstraße.5, 40225 Düsseldorf, Germany;2. Institute of Physical Biology, Heinrich-Heine-Universität, 40225 Düsseldorf, Germany;3. Institute of Structural Biochemistry (ICS-6), Research Centre Jülich, 52425 Jülich, Germany;4. Clinic for Gastroenterology, Hepatology and Infectious Diseases, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany;5. Institute for Pharmaceutical and Medicinal Chemistry, Department of Mathematics and Natural Sciences, Heinrich-Heine-University, Düsseldorf, Germany;6. John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), Institute for Complex Systems - Structural Biochemistry (ICS-6) Research Centre Jülich, 52425 Jülich, Germany;1. Laboratory of Physiopathology of Pregnancy and Labor, Center for Pharmacological and Botanical Studies, National Research Council, School of Medicine, University of Buenos Aires, Argentina;2. Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA;3. Biomedicine Research Institute of Buenos Aires, Partner Institute of the Max Planck Society (MPSP), National Research Council, Ciudad Autónoma de Buenos Aires (CABA), Buenos Aires, Argentina;4. Laboratory of Molecular Endocrinology, Center for Pharmacological and Botanical Studies, National Research Council, School of Medicine, University of Buenos Aires, Argentina;1. Center of Physiology and Pharmacology, Institute of Physiology, Medical University of Vienna, Vienna, Austria;2. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria;3. Center of Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria |
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| Abstract: | The role of platelets in the sex difference observed in mouse thrombosis models was evaluated by examining platelet diminution in vivo after thrombotic challenge, and aggregation of mouse platelets in PRP. A fall in platelet count was observed in both sexes after i.v. injection of either arachidonic acid or the thromboxane agonist, U46619. Platelet diminution induced by high dose arachidonate (50 mg/kg) was significantly greater in males compared to female mice. Responses to U46619 were similar in both sexes. In PRP, male platelets exhibited a greater response than female platelets to both ADP (15 uM) and arachidonate (0.3 mM), but not to U46619 (4.6 and 6.9 uM). These results suggest that the gender difference in arachidonate-induced sudden death, in which males are more susceptible than females, is related to a sex difference in mouse platelet function. |
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