| 1,3-二羰基衍生物的合成及胰岛素增敏活性研究 |
| |
| 引用本文： | 王火权,李煜,汤磊. 1,3-二羰基衍生物的合成及胰岛素增敏活性研究[J]. 海峡药学, 2005, 17(2): 121-124 |
| |
| 作者姓名： | 王火权 李煜 汤磊 |
| |
| 作者单位： | 杭州市萧山第一人民医院药剂科,杭州,311200;贵阳医学院药学院,贵阳,550004 |
| |
| 摘 要： | 目的合成1．3-二羰基衍生物并检测其胰岛素增敏活性。方法在化合物1的基础上合成了5个目标化合物，用3T3-L1前脂肪细胞对这些化合物进行了胰岛素增敏活性筛选。结果化合物3在3T3-L1脂肪细胞模型上表现出较强的胰岛素增敏活性。结论化合物3可能在体内具有降糖活性，拟选送进行体内降糖活性测试。
|
| 关 键 词： | 胰岛素增敏活性 3T3-L1细胞 2型糖尿病 |
| 文章编号： | 1006-3765(2005)02-0121-04 |
Preparation and Insulin-sensitizing Activity of Some 1,3-dicarbonyl Derivatives |
| |
| WANG Huo-quan,LI Yu,TANG Lei. Preparation and Insulin-sensitizing Activity of Some 1,3-dicarbonyl Derivatives[J]. Strait Pharmaceutical Journal, 2005, 17(2): 121-124 |
| |
| Authors: | WANG Huo-quan LI Yu TANG Lei |
| |
| Affiliation: | WANG Huo-quan 1,LI Yu 2,TANG Lei 2 |
| |
| Abstract: | OBJECTIVE To synthesize and test the insulin-sensitizing activities of some 1,3-dicabonyl derivatives.METHODS 5 title compounds were synthesized on the basis of compound 1, and their insulin-sensitizing activities were evaluated on 3T3-L1 preadipocyte cells.RESULTS Compound 3 showed strong insulin-sensitizing activity in vitro.CONCLUSION Compound 3 may possess good sugar-lowering activity, and was selected for further hypoglycemic evaluation in vivo. |
| |
| Keywords: | Insulin-sensitizing activity 3T3-L1 cells type 2 diabetes |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
