A comparative study on the antinociceptive and anti-inflammatory activities of five Juniperus taxa |
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Authors: | Esra Küpeli Akkol Ayegül Güven Erdem Yesilada |
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Institution: | aGazi University, Faculty of Pharmacy, Department of Pharmacognosy, Etiler 06330, Ankara, Turkey;bAnkara University, Faculty of Pharmacy, Department of Pharmaceutical Botany, Tandogan 06100, Ankara, Turkey;cYeditepe University, Faculty of Pharmacy, Department of Pharmacognosy, Kayısdagı 34755, Istanbul, Turkey |
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Abstract: | Ethnopharmacological relevanceJuniperus L. (Cupressaceae) species have been used to various inflammatory and infectious diseases such as bronchitis, colds, cough, fungal infections, hemorrhoids, gynecological diseases, and wounds in Turkish folk medicine.Aim of the studyTo evaluate this traditional information, anti-inflammatory and antinociceptive activities of the methanolic and aqueous extracts prepared from different parts (stem, fruit and leaves) of the five Turkish taxa under Juniperus section of the gender; J. drupacea, J. communis var. communis, J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, and J. oxycedrus subsp. macrocarpa growing were investigated.MethodsFor the anti-inflammatory activity, carrageenan-induced and PGE2-induced hind paw edema models, and for the antinociceptive activity p-benzoquinone-induced writhing and hot plate tests in mice were employed.ResultsThe methanolic extracts of fruit and leaves from J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis exhibited notable inhibition in carrageenan-induced edema model at a dose of 100 mg/kg. The same extracts also displayed significant activity against PGE2-induced edema model. While, the remaining extracts were found inactive against these edema models. A similar activity pattern was observed against p-benzoquinone-induced abdominal constriction test without inducing any gastric damage or apparent acute toxicity, whereas all extracts were inactive in hot plate test.ConclusionThe experimental data demonstrated that J. oxycedrus subsp. oxycedrus and J. communis var. saxatilis displayed remarkable anti-inflammatory and antinociceptive activities; however, further studies are warranted to define and isolate the active anti-inflammatory and antinociceptive components from these active species which may yield safe and effective agents to be used in the treatment of inflammatory disorders. |
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Keywords: | Anti-inflammatory activity Antinociceptive activity Carrageenan-induced edema Juniperus species p-Benzoquinone-induced writhes Prostaglandin E2-induced edema |
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