| 肝脾γδT细胞淋巴瘤的临床病理学观察 |
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| 引用本文： | 耿舰,朱梅刚,丁彦青,韩慧霞.肝脾γδT细胞淋巴瘤的临床病理学观察[J].第一军医大学学报,2004,24(1):88-90. |
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| 作者姓名： | 耿舰 朱梅刚 丁彦青 韩慧霞 |
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| 作者单位： | 第一军医大学南方医院病理科,广东广州510515 |
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| 摘 要： | 目的 探讨肝脾γδT细胞淋巴瘤的临床病理学特征和免疫表型。方法 应用常规病理、免疫组化观察1例肝脾γδT细胞淋巴瘤并对相关文献进行调研。结果 患者肝脾明显增大，镜下显示瘤细胞弥漫浸润脾脏红髓血窦，瘤细胞中等大，胞浆淡染，核染色质较细腻，核仁不明显。肝脏血窦内瘤细胞呈佛珠状或线样浸润，免疫表型：瘤细胞表达CD45RO、CD3和TIA-1，而CD57、CD20和CD79a等标记阴性。结论 肝脾γδT细胞淋巴瘤是较为罕见的外周T细胞淋巴瘤，预后较差，应注意与其他淋巴瘤和白血病的鉴别。
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| 关 键 词： | 肝脾γδT细胞淋巴瘤 病理学特征 免疫表型 鉴别诊断 诊断 |
Hepatosplenic gammadeltaT-cell lymphoma: a clinicopathological study] |
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| Jian Geng,Mei-gang Zhu,Yan-qing Ding,Hui-xia Han.Hepatosplenic gammadeltaT-cell lymphoma: a clinicopathological study][J].Journal of First Military Medical University,2004,24(1):88-90. |
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| Authors: | Jian Geng Mei-gang Zhu Yan-qing Ding Hui-xia Han |
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| Institution: | Department of Pathology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. geng@fimmu.com |
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| Abstract: | OBJECTIVE: To explore the clinicopathologic features and immunophenotype of hepatosplenic gammadeltaT-cell lymphoma. METHODS: A case of hepatosplenic gammadeltaT-cell lymphoma was studied with conventional histopathological and immunohistochemical staining in combination of literature review. RESULTS: Diffuse hepatic and splenic enlargement was found in this case. Microscopically, the liver and spleen showed marked sinusoidal infiltration. The cells of hepatosplenic T-cell lymphoma were homogeneous, medium in size with pale cytoplasm, and the nuclear chromatin was loosely condensed with small inconspicuous nucleoli. The neoplastic cells were positive for CD45RO, CD3 and TIA-1, but negative for CD57, CD20 and CD79a. CONCLUSION: Hepatosplenic gammadeltaT-cell lymphoma is a rare form of peripheral T-cell lymphoma and has usually poor prognosis, which should be differentiated from other lymphomas or leukemia. |
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