| 固定多粘菌素B的新型吸附剂对血液中细菌内毒素吸附性能的实验研究 |
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| 引用本文： | 李苑,王翔,熊兴良,邵阳,高玮,蔡绍皙.固定多粘菌素B的新型吸附剂对血液中细菌内毒素吸附性能的实验研究[J].生物医学工程学杂志,2006,23(4):832-835. |
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| 作者姓名： | 李苑 王翔 熊兴良 邵阳 高玮 蔡绍皙 |
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| 作者单位： | 重庆大学,教育部生物力学与组织工程重点实验室,重庆,400044 |
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| 基金项目： | 教育部访问学者基金;重庆市科技攻关项目 |
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| 摘 要： | 研究了固定有多粘菌素B（Polymyxin B,PMB）短肽的聚苯乙烯微球对血浆中细菌内毒素的亲和吸附性能，讨论了不同吸附条件对吸附性能的影响。用纯种大白鼠作为实验动物，建立内毒索血症动物模型。用固定有PMB短肽的聚苯乙烯微球对动物模型进行血液灌流实验，观察该吸附剂血液灌流清除血浆中内毒素的功效，考察了接有PMB短肽的聚苯乙烯微球的血液相容性及其对蛋白的影响。实验结果表明。采用血液灌流吸附疗法成功地清除动物模型血液中的内毒素，而且，固定有多粘菌素B的特异吸附剂具有良好的血液相容性。
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| 关 键 词： | 多粘菌素B 内毒素 血液灌流 血液相容性 |
| 收稿时间： | 2003-07-10 |
| 修稿时间： | 2003-07-102004-12-07 |
Experimental Study on a Novel Affinity Adsorbent for Removal of Endotoxin in Plasma |
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| Li Yuan,Wang Xiang,Xiong Xingliang,ShaoYang,Gao Wei,Cai Shaoxi.Experimental Study on a Novel Affinity Adsorbent for Removal of Endotoxin in Plasma[J].Journal of Biomedical Engineering,2006,23(4):832-835. |
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| Authors: | Li Yuan Wang Xiang Xiong Xingliang ShaoYang Gao Wei Cai Shaoxi |
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| Institution: | Key Lab for Biomechanical & Tissue Engineering under the State Ministry of Education, Chongqing University,Chongqing 400044, China. |
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| Abstract: | In this paper, the adsorbent properties of Polymyxin B immobilized polystyrene microbeads to remove endotoxin from plasma were studied and the factors that affected the absorption of endotoxin were discussed. The rabbit models of endoxemia were established,which were used in hemoperfusion. The experiment results indicated that the novel affinity adsorbent could remove endotoxin from plasma effectively. Moreover. the results also showed that Polymyxin B immobilized polystyrene microbeads was a fine biomaterial of hemoperfusion as well as exhibited a satisfactory blood compatibility. |
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| Keywords: | Polymyxin B(PMB) Endotoxin Hemoperfusion Blood compatibility |
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