Normal differential renal function does not indicate a normal kidney after partial ureteropelvic obstruction and subsequent relief in 2-week-old piglets |
| |
Authors: | Thomas H Dissing Anni Eskild-Jensen Mette Marie Mikkelsen Michael Pedersen Jørgen Frøkiær Jens Christian Djurhuus Isky Gordon |
| |
Institution: | (1) Institute of Clinical Medicine, University of Aarhus, Aarhus, Denmark;(2) Department of Nuclear Medicine, Aarhus Sygehus, Aarhus University Hospital, Aarhus, Denmark;(3) Institute of Child Health, University College London, London, UK;(4) Radiology and Physics Unit, Institute of Child Health, University College London, Guilford Street, London, WC1N1EH, UK |
| |
Abstract: | Purpose We investigated the functional consequences of relieving ureteric obstruction in young pigs with experimental hydronephrosis
(HN) induced by partial unilateral ureteropelvic obstruction.
Materials and methods Three groups of animals were followed from the age of 2 weeks to the age of 14 weeks: Eight animals had severe or grades 3–4
HN throughout the study. Six animals had relief of the obstruction after 4 weeks. Six animals received sham operations at
both ages. Morphological and functional examinations were performed at age 6 weeks and again at age 14 weeks and consisted
of magnetic resonance imaging (MRI), technetium-diethylenetriaminepentaaceticacid (99mTc-DTPA) renography, renal technetium-dimercaptosuccinicacid (99mTc-DMSA) scintigraphy, and glomerular filtration rate (GFR) measurement.
Results After relief of the partial obstruction, there was reduction of the pelvic diameter and improvement of urinary drainage. Global
and relative kidney function was not significantly affected by either obstruction or its relief. Renal 99mTc-DMSA scintigraphy showed a change in both the appearance of the kidney and a change in the distribution within kidneys
even after relief of obstruction.
Conclusion This study shows that partial ureteric obstruction in young pigs may be associated with little effect on global and differential
kidney function. However, even after relief of HN, the distribution of 99mTc-DMSA in the kidney remains abnormal suggesting that a normal differential renal function may not represent a normal kidney. |
| |
Keywords: | Kidney Hydronephrosis Ureter Ureteral obstruction Swine |
本文献已被 PubMed SpringerLink 等数据库收录! |
|