医院感染肺炎克雷伯菌连续6年耐药性监测研究

目的 观察和监测医院感染肺炎克雷伯菌对抗菌药物的耐药变化及产超广谱β-内酰胺酶（ESBLs）菌株的发生率。方法 连续检测1999-2004年医院感染肺炎克雷伯菌的耐药状况,药敏试验采用K-B纸片法,结果判定依据美国临床实验室标准化委员会（NCCLS）标准。结果 肺炎克雷伯菌对亚胺培南全部敏感,头孢他啶、头孢吡肟、头孢哌酮/舒巴坦对肺炎克雷伯菌亦有很好的抗菌活性,对其他抗菌药物耐药率有逐年升高趋势,ESBLs总阳性率为20.2%。结论 及时总结医院感染肺炎克雷伯菌的耐药菌变迁规律,具有十分重要的临床意义。

Surveillance of Antimicrobial Resistance of Klebsiella pneumoniae in Nosocomial Infections During 1999-2004

OBJECTIVE A surveillance study was performed for nosocomial infections in order to investigate the change in antimicrobial resistance of Klebsiella pneumoniae,especially the strains isolated from 1999 to 2004.METHODS K-B test was used for the antibiotics susceptibility test and the results were read based on National Committee for Clinical Laboratory Standards(NCCLS) of the USA.The situation of ESBLs-producing strains of K.pneumoniae was investigated.RESULTS Totally 326 K.pneumoniae strains showed the highest susceptibility to imipenem.Ceftazidime,cefepime,and cefoperazone/sulbactam also showed excellent activity against K.pneumoniae.The prevalence of ESBLs from 326 strains was 20.2%.CONCLUSIONS It is important to study the drug resistance in nosocomial infections by K.pneumoniae.