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医院感染肺炎克雷伯菌连续6年耐药性监测研究
引用本文:童能胜,鞠萍,骆明惠,柯才明,黎增文,刘俊峰,朱胜洪.医院感染肺炎克雷伯菌连续6年耐药性监测研究[J].中华医院感染学杂志,2007,17(5):589-590.
作者姓名:童能胜  鞠萍  骆明惠  柯才明  黎增文  刘俊峰  朱胜洪
作者单位:黄石市第二医院,湖北,黄石,435000
摘    要:目的 观察和监测医院感染肺炎克雷伯菌对抗菌药物的耐药变化及产超广谱β-内酰胺酶(ESBLs)菌株的发生率。方法 连续检测1999-2004年医院感染肺炎克雷伯菌的耐药状况,药敏试验采用K-B纸片法,结果判定依据美国临床实验室标准化委员会(NCCLS)标准。结果 肺炎克雷伯菌对亚胺培南全部敏感,头孢他啶、头孢吡肟、头孢哌酮/舒巴坦对肺炎克雷伯菌亦有很好的抗菌活性,对其他抗菌药物耐药率有逐年升高趋势,ESBLs总阳性率为20.2%。结论 及时总结医院感染肺炎克雷伯菌的耐药菌变迁规律,具有十分重要的临床意义。

关 键 词:医院感染  肺炎克雷伯菌  抗药性  病原菌
文章编号:1005-4529(2007)05-0589-02
收稿时间:2006-07-05
修稿时间:2006-07-052006-10-10

Surveillance of Antimicrobial Resistance of Klebsiella pneumoniae in Nosocomial Infections During 1999-2004
TONG Neng-sheng,JU Ping,LUO Ming-hui,KE Cai-ming,LI Zeng-wen,LIU Jun-feng,ZHU Sheng-hong.Surveillance of Antimicrobial Resistance of Klebsiella pneumoniae in Nosocomial Infections During 1999-2004[J].Chinese Journal of Nosocomiology,2007,17(5):589-590.
Authors:TONG Neng-sheng  JU Ping  LUO Ming-hui  KE Cai-ming  LI Zeng-wen  LIU Jun-feng  ZHU Sheng-hong
Institution:The Second Hospital of Huangshi, Huangshi, Hubei 435000, China
Abstract:OBJECTIVE A surveillance study was performed for nosocomial infections in order to investigate the change in antimicrobial resistance of Klebsiella pneumoniae,especially the strains isolated from 1999 to 2004.METHODS K-B test was used for the antibiotics susceptibility test and the results were read based on National Committee for Clinical Laboratory Standards(NCCLS) of the USA.The situation of ESBLs-producing strains of K.pneumoniae was investigated.RESULTS Totally 326 K.pneumoniae strains showed the highest susceptibility to imipenem.Ceftazidime,cefepime,and cefoperazone/sulbactam also showed excellent activity against K.pneumoniae.The prevalence of ESBLs from 326 strains was 20.2%.CONCLUSIONS It is important to study the drug resistance in nosocomial infections by K.pneumoniae.
Keywords:Nosocomial infection  Klebsiella pneumoniae  Drug-reslstance  Pathogen
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