| 造血干细胞移植治疗儿童白血病若干问题 |
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| 引用本文： | 黄绍良,周敦华. 造血干细胞移植治疗儿童白血病若干问题[J]. 临床儿科杂志, 2007, 25(8): 625-628,632 |
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| 作者姓名： | 黄绍良 周敦华 |
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| 作者单位： | 中山大学附属第二医院儿科,广东广州,510120 |
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| 摘 要： | 该文涉及各类儿童造血干细胞移植(HSCT),如骨髓移植(BMT)、外周血造血干细胞移植(PBSCT)和脐血移植(UCBT)治疗白血病的优缺点及HSCT在儿童白血病治疗中的地位。绝大多数儿童白血病可通过正规联合化疗根治,仅少数(约20%)高危、难治及复发的白血病是异基因HSCT的适应证,无适合的同胞供体时,可选择HLA全相合非血缘相关BMT或PBSCT,UD-UCBT更适合于儿童患者。
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| 关 键 词： | 造血干细胞移植 白血病 儿童 |
| 文章编号： | 1000-3606（2007）08-625-04 |
| 修稿时间： | 2007-04-27 |
Treatment for childhood leukemia by hematopoietic stem cell transplantation |
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| HUANG Shao-liang,ZHOU Dun-hua. Treatment for childhood leukemia by hematopoietic stem cell transplantation[J]. The Journal of Clinical Pediatrics, 2007, 25(8): 625-628,632 |
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| Authors: | HUANG Shao-liang ZHOU Dun-hua |
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| Affiliation: | Department of Pediatrics, The Second Affiliated Hospital Sun Yat-Sen University, Guangzhou 510120, Guangdong, China |
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| Abstract: | Advantages and disadvantages,indicators of hematopoietic stem cell transplantation including bone marrow transplantation,peripheral blood stem cell transplant and umbilical cord blood transplantation in treatment of childhood leukemia were reviewed.Most of children with leukemia can be radically cured by regular and combined chemothera-py.Only a minority(approximately 20%)of high-risk,refractory or relapsed leukemia cases needs allogeneic hematopoie-tic stem cell transplantation,HLA-matched unrelated donor bone marrow transplantation or peripheral blood stem cell transplantation can be chosen when there are no suitable sibling donors.Unrelated donor umbilical cord blood transplantation is more suitable for pediatric patients. |
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| Keywords: | hematopoietic stem cell transplantation leukemia childhood |
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