| 蒽环类药物对白血病细胞的细胞毒作用与活性氧的关系研究进展 |
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| 引用本文： | 张娜,蒋慧.蒽环类药物对白血病细胞的细胞毒作用与活性氧的关系研究进展[J].临床儿科杂志,2007,25(8):711-713. |
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| 作者姓名： | 张娜 蒋慧 |
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| 作者单位： | 上海交通大学附属儿童医院,上海,200040 |
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| 摘 要： | 蒽环类抗生素用于白血病的治疗已30余年历史,已成为化疗不可缺少的药物之一。近年来研究显示,蒽环类抗生素对白血病细胞的细胞毒作用包括凋亡。而活性氧(reactive oxygen species,ROS)是细胞增殖、分化、成熟及凋亡过程中的重要介质;同时它与细胞耐药、心脏毒性有关。研究其作用机制将更好地了解白血病化疗的机制,更好地指导临床治疗。文章简述了蒽环类药物的作用机制及ROS与蒽环类药物细胞毒作用的关系,以期为临床研究提供参考。
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| 关 键 词： | 蒽环类药物 凋亡 活性氧 白血病 |
| 文章编号： | 1000-3606（2007）08-711-03 |
| 修稿时间： | 2006-08-25 |
Recent advances of reactive oxygen species and cytotoxicity of anthracycline on leukemia cells |
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| ZHANG Na,JIANG Hui.Recent advances of reactive oxygen species and cytotoxicity of anthracycline on leukemia cells[J].The Journal of Clinical Pediatrics,2007,25(8):711-713. |
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| Authors: | ZHANG Na JIANG Hui |
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| Abstract: | Anthracycline has been used to treat leukemia for over thirty years.It has become one of the most essential drugs of chemotherapeutics.For the past a few years,researches have shown that reactive oxygen species(ROS)are generated,when anthracycline antibiotics act on leukemia cells,as important mediator of cells proliferation,diffe-rentiation,maturation and apoptosis.It also relates with drug resistance and heart toxicity.Study on anthracycline antibio-tics is useful to know more about its chemotherapy mechanism and to guide treatment.The advances of ROS and cytotoxicity of anthracycline antibiotics on leukemia cells is reviewed. |
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| Keywords: | anthracycline apoptosis reactive oxygen species leukemia |
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