Technetium Tc 99m plasmin in the diagnosis of inflammatory disease |
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| Authors: | Azu Owunwanne David A Weber Irving L Spar George A Wilson Robert E O'Mara |
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| Institution: | (1) Division of Nuclear Medicine, Department of Radiology, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA;(2) Department of Radiation Biology and Biophysics, University of Rochester, School of Medicine and Dentistry, Rochester, New York, USA;(3) Present address: Department of Radiology and Nuclear Medicine, Faculty of Medicine, Kuwait University, P.O. Box 24923, Kuwait |
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| Abstract: | The localization characteristics of technetium Tc 99m plasmin were studied in experimental animals to investigate the use of99mTc-plasmin for imaging inflammatory processes. At various times after abscess induction using turpentine in rats, the in vivo distribution properties of99mTc-plasmin, gallium citrate Ga 67,125I-fibrinogen, and99mTc-human serum albumin (HSA) were studied by gamma-camera imaging. The in vivo binding of each radiopharmaceutical was also tested in rat and human plasma clots. Region-of-interest analyses of gamma-camera images showed relatively poor99mTc-plasmin localization at sites of abscess formation. The ratio of abscess-to-control activity of this radiopharmaceutical did not exceed that of67Ga,125I-fibrinogen, or99mTc-HSA. In vitro assays of each of the radiopharmaceuticals in plasma clots showed99mTc-phasmin and125I-fibrinogen to have the best localization characteristics. |
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| Keywords: | 99mTc-plasmin Inflammatory disease |
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