A further note on the sampling device for the anti-mutagenicity of saliva |
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Authors: | Masahiro Toda Kanehisa Morimoto Sei-ichi Nakamura Kazuo Hayakawa |
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Affiliation: | (1) Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-Oka, 565-0871 Sutta, Osaka, Japan;(2) Health Research Foundation, Kyoto;(3) Department of Commonity Health School of Health Sciences, Osaka University, Osaka |
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Abstract: | Objectives The purpose of this study was to compare the anti-mutagenicity of Salivette and test-tube sampling saliva. In addition, the relation between the inhibiting and pH-buffering capacities of saliva was investigated. Methods Subjects were 52 healthy female university students. The collection of saliva samples was carried out using 2 sampling devices; test-tube and Salivette. The anti-mutegenicity of the saliva was measured using the umu test. Results The inhibiting capacity of Salivette-saliva was significantly lower compared with that of testube-saliva (p<0.01,t test). However, there was a significant correlation between them (r=0.35; p<0.05). In addition, there was a significant correlation between the inhibiting and pH-buffering capacities of saliva (r=−0.36; p<0.05). Conclusions These findings suggest that both the Salivette and the test-tube may be appropriate as saliva-sampling devices. In addition, they suggest that the bicarbonates might inhibit the anti-mutagenicity of saliva, or that the activity of substances related to the anti-mutagenicity of saliva might be dependent on pH. |
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Keywords: | anti-mutagenicity human saliva umu test saliva sampling device buffering capacity |
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