| 髋关节发育不良的分子遗传学研究进展 |
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| 引用本文： | 范建波,史冬泉,蒋青. 髋关节发育不良的分子遗传学研究进展[J]. 中华医学遗传学杂志, 2009, 26(6). DOI: 10.3760/cma.j.issn.1003-9406.2009.06.015 |
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| 作者姓名： | 范建波 史冬泉 蒋青 |
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| 作者单位： | 南京医科大学附属鼓楼临床医学院关节中心,210008 |
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| 摘 要： | 流行病学研究证实遗传因素在发育性髋关节发育不良(developmental dysplasia of the hip,DDH)发病中具有重要作用.研究发现67.88%的DDH与遗传因素有关,32.12%的DDH与环境因素有关.目前有关该病诊断和治疗方面的研究已得到不断发展,但在遗传病因学方面仍未有明确结论.本文就髋关节发育不良候选基因及其定位研究的进展作一简要综述.
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| 关 键 词： | 发育性髋关节发育不良 遗传学 易感基因 遗传多态性 |
Progress in researches on the molecular genetics of developmental dysplasia of the hip |
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| Abstract: | Epidemiological studies have confirmed that genetic factors play an important role in the incidence of developmental dysplasia of the hip(DDH).Previous studies showed that genetic factors accounted for a major part(about 67.88%),the remaining part was due to the environmental factors.At present,great progress has been made in the researches of the diagnosis and treatment of DDH,but there is no clear conclusion in the genetic etiology.This article reviews the latest studies of candidate genes and their mapping. |
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| Keywords: | developmental dysplasia of the hip genetics susceptibility gene genetic polymorphism |
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