| 视网膜母细胞瘤发病机制的分子生物学研究回顾与进展 |
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| 引用本文： | 李雁,张军军.视网膜母细胞瘤发病机制的分子生物学研究回顾与进展[J].国际眼科杂志,2010,10(4):703-705. |
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| 作者姓名： | 李雁 张军军 |
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| 作者单位： | 四川大学华西医院眼科,中国四川省成都市,610041 |
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| 摘 要： | 视网膜母细胞瘤(retinoblastoma,RB)是婴幼儿最常见的一种眼内恶性肿瘤,不仅严重影响患儿的视力,更危及生命。随着生物学技术的迅猛发展,RB的生物学研究已取得一些突破,探讨RB的发病机制对抑制肿瘤的生长和转移,提高患儿的生存率,具有重要的临床意义。现将视网膜母细胞瘤发病机制的研究进展综述如下。
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| 关 键 词： | 视网膜母细胞瘤 基因突变 p53 鼠双微粒体2 Rb蛋白 |
Review and progress of retinoblastoma pathogenesis in molecular biology |
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| Yan Li and Jun-Jun Zhang.Review and progress of retinoblastoma pathogenesis in molecular biology[J].International Journal of Ophthalmology,2010,10(4):703-705. |
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| Authors: | Yan Li and Jun-Jun Zhang |
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| Institution: | Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China;Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China |
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| Abstract: | Retinoblastoma is a common pediatric eye malignant tumor, it not only seriously affects children’s eyesight, but also endangers their lives. With the rapid development of biological technology, some breakthroughs have been made in retinoblastoma biological research. It has an important clinical significance to explore the pathogenesis of retinoblastoma in order to inhibit tumor growth and metastasis and improve the survival rate of children. Now the pathogenesis of retinoblastoma research is summarized. |
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| Keywords: | p53 |
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