| 药物预防阵发性房颤复发的疗效与安全性评价 |
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| 引用本文： | 骆雷鸣,陈敏芝,史军,张灵,杨雪,朱启伟. 药物预防阵发性房颤复发的疗效与安全性评价[J]. 药物不良反应杂志, 2004, 6(3): 151-154 |
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| 作者姓名： | 骆雷鸣 陈敏芝 史军 张灵 杨雪 朱启伟 |
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| 作者单位： | 中国人民解放军总医院,北京,100853 |
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| 摘 要： | 目的评价不同抗心律失常药物在预防阵发性房颤复发中的疗效及安全性。方法随机入选阵发性房颤转复患者,随机分为胺碘酮、普罗帕酮、阿替洛尔和对照组,接受不同药物治疗,并定期随访,终点为一年。结果小剂量胺碘酮与普罗帕酮均可以降低房颤复发率,延长窦性节律时间,缩短再发房颤持续时间,胺碘酮的作用优于普罗帕酮。两者的毒副作用差别不大,发生率低。结论小剂量胺碘酮和普罗帕酮均可作为预防阵发性房颤的首选药物,近期疗程的毒副作用发生率低、安全性高。
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| 关 键 词： | 房颤复发 抗心律失常药物 疗效及安全性 |
| 文章编号： | 1008-5734(2004)3-0151-04 |
Efficacy and safety of antiarrhythmics for prevention of recurrence of paroxysmal atrial fibrillation |
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| Luo Leiming,Chen Minzhi,Shi Jun,Zhang Ling,Yang Xue,Zhu Qiwei. Efficacy and safety of antiarrhythmics for prevention of recurrence of paroxysmal atrial fibrillation[J]. Adverse Drug Reactions Journal, 2004, 6(3): 151-154 |
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| Authors: | Luo Leiming Chen Minzhi Shi Jun Zhang Ling Yang Xue Zhu Qiwei |
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| Abstract: | Objective: To evaluate the efficacy and safety of antiarrhythmics for prevention of recurrence of paroxysmal atrial fibrillation(PAF). Methods: Patients with PAF were randomly divided into three groups treated with amiodarone, propafenone and atenolol respectively, and a control group. They were followed up regularly for a year. Results: Low-dose amiodarone and propafenone could reduce recurrence rate of atrial fibrillation and shorten its lasting time and extend the time of sinus rhythm. Amiodarone is better than propafenone in efficacy and both show little difference in adverse effects. Conclusion: Low-dose amiodarone and propafenone could be first-choice drugs to prevent PAF with high safety and low incidence of adverse effects. |
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| Keywords: | atrial fibrillation recurrence antiarrhythmics efficacy/safety |
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