| PROTECTIVE ACTION OF BUDIPINE AGAINST MPTP NEUROTOXICITY |
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| 作者姓名： | 盛锦根 徐德隆 余慧贞 徐修蓉 唐琴梅 |
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| 作者单位： | Department of Neurology，Ruijin Hospital，SSMU，Shanghai，Department of Neurology，Ruijin Hospital，SSMU，Shanghai，Department of Neurology，Ruijin Hospital，SSMU，Shanghai，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai |
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| 摘 要： | Mice treated with large dose of MPTP showed a reduction in the levels of DA, 5-HT and their metabolites in the striatum. The average levels as compared with the control were reduced by 94% for DA (P<0.001), 61% for DOPAC (P<0.05), 65% for HVA (P<0.01). 5-HT and 5-HIAA were lower than detection limits. In mice pretreated with budipine, although the striatal dopamine level was also reduced, mean DA and 5-HT levels were significantly higher than those in mice given MPTP alone. This result suggested that budipine can partially prevent the MPTP neurotoxicity.
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PROTECTIVE ACTION OF BUDIPINE AGAINST MPTP NEUROTOXICITY |
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| Sheng Jingen,Xu Delong Yu Huizhen.PROTECTIVE ACTION OF BUDIPINE AGAINST MPTP NEUROTOXICITY[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1990(2). |
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| Authors: | Sheng Jingen Xu Delong Yu Huizhen |
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| Institution: | Sheng Jingen,Xu Delong Yu Huizhen Department of Neurology,Ruijin Hospital,SSMU,Shanghai Xu Xiurong,Tang Qinmei Shanghai Institute of Materia Medica,Academia Sinica,Shanghai |
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| Abstract: | Mice treated with large dose of MPTP showed a reduction in the levels of DA, 5-HT and their metabolites in the striatum. The average levels as compared with the control were reduced by 94% for DA (P<0.001), 61% for DOPAC (P<0.05), 65% for HVA (P<0.01). 5-HT and 5-HIAA were lower than detection limits. In mice pretreated with budipine, although the striatal dopamine level was also reduced, mean DA and 5-HT levels were significantly higher than those in mice given MPTP alone. This result suggested that budipine can partially prevent the MPTP neurotoxicity. |
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| Keywords: | budipine MPTP dopamine |
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