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Association between IL28B polymorphisms and first-phase viral load decrease in chronic hepatitis C virus-infected patients treated with peginterferon alfa-2b/ribavirin |
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| Authors: | Arends Joop E Fransen Justin H Hoepelman Andy I M van Baarle Debbie |
| Affiliation: | aDepartment of Internal Medicine and Infectious Diseases, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands;bDepartment of Immunology, University Medical Center Utrecht (UMCU), Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands |
| Abstract: | Host polymorphisms in the IL28B region have recently been associated with outcome of treatment for hepatitis C virus (HCV) infection. This study clearly shows an association between first-phase viral load decrease and the IL28B rs12979860 polymorphism in chronic HCV-infected patients. Furthermore, a higher treatment efficiency factor (?) was found in those HCV-infected patients with a CC genotype compared with those with a CT and TT genotype. This study highlights the importance of host response mechanisms in relation to favourable clearance of HCV. |
| Keywords: | IL28B Hepatitis C Single nucleotide polymorphism |
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