早期胎传梅毒38例临床分析

目的:探讨早期胎传梅毒的临床特征。方法:回顾性分析38例早期胎传梅毒患儿的临床表现、实验室检查特点以及治疗后TRUST、TPPA滴度变化情况。结果:38例早期胎传梅毒患儿中,大多数临床表现为肝脾肿大、早产、低出生体重、皮肤损害、肺炎、心肌损害以及骨骼损害、贫血等,少数并发多系统器官功能衰竭;血清学检查TRUST、TPPA滴度均明显升高,经青霉素治疗2-3天后绝大多数患儿临床症状好转或消失,TRUST、TPPA滴度均明显下降或转阴。结论:早期胎传梅毒临床表现多样,绝大多数患儿青霉素治疗后疗效显著,伴有早产、低体重以及多系统器官功能衰竭者死亡率高。

Clinical analysis of 38 infants with early congenital syphilis

Objective:To investigate the clinical characteristics of early congenital syphilis.Methods:38 cases of early congenital syphilis were retrospectively studied on the characteristics of clinical and laboratory and the change of TRUST,TPPA after treatment.Results:Most of the cases presented hepatosplenomegaly,premature delivery,low birth weight,cutaneous lesions,pneumonia,cardiac muscle lesion and bone lesion,anemia etc.Few of the cases presented multiple organ failure.Both TPPA and TRUST of serological tests were significantly increased.By the end of 2~3 days after treatment of penicillin,the clinical symptoms improved or resolved of most the cases,meanwhile the TRUST and TPPA also were significantly decreased or had become negative.Conclusion:The clinical characteristics of early congenital syphilis are multiplicity.Most of the cases can be treated effectively by penicillin.But the risk of treatment failure is significantly increased when low birth weight,premature delivery and MODS are present.