| 16例9号染色体臂间倒位的遗传学分析 |
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| 引用本文： | 张萍,白凤霞,陈景玉. 16例9号染色体臂间倒位的遗传学分析[J]. 检验医学与临床, 2012, 0(22): 2801-2801,2803 |
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| 作者姓名： | 张萍 白凤霞 陈景玉 |
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| 作者单位： | 重庆医科大学附属第二医院血液科,400010 |
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| 摘 要： | 目的对重庆医科大学附属第二医院血液科2005～2011年检出的16例9号染色体臂间倒位[inv(9)]患者的遗传效应进行分析,明确inv(9)与不孕不育、流产、死胎等的关系。方法采集患者2～3mL肝素抗凝外周血,常规培养制备染色体,G显带、C显带证实。结果在1 300例受检者中,检出inv(9)患者16例,发生率为1.2%。由此说明inv(9)在异常生育患者于检出率明显高于一般人群。结论 inv(9)具有遗传效应,携带者应做产前诊断。
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| 关 键 词： | 9号染色体 臂间倒位 遗传效应 |
Genetic effect of pericentric of chromosome 9 |
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| ZHANG Ping,BAI Feng-xia,CHEN Jing-yu. Genetic effect of pericentric of chromosome 9[J]. Laboratory Medicine and Clinic, 2012, 0(22): 2801-2801,2803 |
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| Authors: | ZHANG Ping BAI Feng-xia CHEN Jing-yu |
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| Affiliation: | (Department of Hematology,the Second College of Clinical Medicine,Chongqing Medical University,Chongqing,400010 China) |
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| Abstract: | Objective To study the genetic effect of pericentric inversion of chromosome 9 and analyse the relationship between pericentric inversion of chromosome 9 and infertility,dead fetus and habitual abortion.Methods The peripheral blood lymphocytes of the patients were cultured routinely for chromosome analysis with G banding and C banding displaying.Results Among 1 300 cases,16 cases were found having pericentric inversion of chromosome 9.The ratio of the group with abnormal fertility（1.2%） was higher than that of the normal fertility group.Conclusion Pericentric inversion of chromosome 9 can result in abnormal fertility. |
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| Keywords: | chromosome 9 percentric inversion genetic effect |
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