组合式配液装置在静脉药物配置中心瓶装药物中的应用

目的探讨静脉药物配置的最佳方法,减少不溶性微粒进入体内。方法以≥10μm和≥25μm不溶性微粒数为指标,采用光阻法对注射用氨苄西林钠在不同配液器具下的复配液进行微粒测定。结果≥10μm不溶性微粒测试中,加入相同数量的药物后两组微粒数量比较,差异具有统计学意义（P〈0.001）;≥25μm微粒的数据分析中,加入1支药物后两组比较,差异无统计学意义（P〉0.05）,加入6支药物后两组比较,差异有显著的统计学意义（P〈0.001）。结论组合式配液装置能明显减少不溶性微粒的产生,且随着加药数目的增多减少较大微粒数量的优越性愈发明显。

Application of combined device in PIVAS vialled medicine

Objective To explore the best way of reducing the insoluble particles enter human body in PIVAS.Methods Taking ≥10μm and ≥25μm insoluble particles as indicator to measure particles in vialled liquid compound using different device in light-resistant way.Results There was significant difference（P0.001）in the test of adding drug in ≥10 μm insoluble particles.No difference in ≥25μm particles by adding one durg.But there was significant difference by adding six durgs.Conclusion The results show that the insoluble particles are reduced obviously by using the combined device and is of great clinical significance in PIVAS.