Unintended consequences: mandatory tuberculin skin testing and severe isoniazid hepatotoxicity |
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Authors: | Lobato Mark N Jereb John A Starke Jeffrey R |
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Institution: | Connecticut Department of Public Health, 410 Capitol Ave, MS 11-TUB, PO Box 340308, Hartford, CT 06134, USA. mark.lobato@ct.gov |
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Abstract: | After mandatory school-enrollment tuberculin skin testing, a 4-year-old girl who was at low risk for Mycobacterium tuberculosis infection had severe isoniazid hepatotoxicity that was managed with a liver transplant. Although severe isoniazid hepatotoxicity is very uncommon in children, this case emphasizes the need to limit skin testing to persons who have a risk factor for infection and to educate parents on how to monitor for adverse effects during treatment. |
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