HBV慢性无症状携带者临床,肝活检,血清标志物的三年随访动态观察

对４６６例ＨＢＶ慢性无症状携带者（ＡＳＣ）进行了为期３年的临床、肝活检及血清标志物的动态观察研究。在此期间，４６６例中有４６例出现临床显性发病，约占样本的１０％，可能与饮酒量过多、乱用药物、精神紧张等因素有关。１４例行第２次肝穿刺，提示：原肝组织正常者几年内相当稳定，病理很少变化，原有病理改变者不易恢复。ＡＳＣＨＢｓＡｇ每年转阴率为１．６３％，抗－ＨＢｓ年转阳率为０．３４％，ＨＢｅＡｇ年转阴率为３．８５％，抗－ＨＢｅ年转阳率为２．７４％，抗－ＨＢｃ无１例阴转。

A THREE-YEAR FOLLOW-UP STUDY OF CLINICAL MANIFESTATIONS,HEPATIC HISTO-PATHOLOGY AND SERUM MARKERS OF 446 ASYMPTOMATIC HBV CARRIERS

three-year follow-up study of the clinic manifestations,liver his-topathology serumHBV markers were made on 466 asymptomatic HBV carriers(ASC).During this period 46patients(10%)became symptomatic and this presumably could be attributed to alcoholicindulgence,medicinals abuse and mental stress.Second liver biopsy was carried out in l4patients and the results revealed that the conditions of the patients with priorl normal liverbiopsy remained so in the following years,but the patients with previous abnormal liverbiopsy scarcely recovered.In patients with ASC,the annual seroconversion rate of HBsAgwas l.63%,that of anti-HBs was 0.34%. The annual seroconversion rates of HBeAg,anti-HBeand anti-HBc were 3.85%,2.74%,and o,respectively.