Efficacy and safety of acarbose in patients with cystic fibrosis and impaired glucose tolerance |
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Authors: | H Kentrup H Bongers M Spengler G Kusenbach H Skopnik |
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Institution: | Kinderklinik der RWTH Aachen, Pauwelsstra?e 30, D-52057 Aachen, Germany, Tel.: +49-241 8089237, Fax: +49 241 8888484, DE Bayer AG, Medical Department, D-51368 Leverkusen, Germany, DE Kinderklinik, Stadtkrankenhaus Worms, Gabriel-von-Seidel-Str. 31, D-67550 Worms, Germany, DE
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Abstract: | Impaired glucose tolerance (IGT) is an increasingly frequent complication of cystic fibrosis (CF). In CF patients, a fast
postprandial rise in plasma glucose is typically followed by a delayed but prolonged insulin response. Patients may develop
symptoms of both hyper- and hypoglycaemia. The α-glucosidase inhibitor, acarbose, delays the hydrolysis and subsequent absorption
of ingested carbohydrates. The aim of this study was to investigate the efficacy of acarbose in CF patients with IGT.
During a 2-week inpatient period for treatment of Pseudomonas infection, 12 CF patients with IGT were studied in a double-blinded, randomized crossover trial. Each patient received acarbose
(50 mg t.i.d.) for 5 days and placebo for 5 days (days 3–8 and days 10–14, respectively). Glucose, insulin and C-peptide responses
to a standardized nutritional load were measured at baseline and at the end of each study period (Days 2, 8 and 14). Treatment
with acarbose was associated with significant reductions in the mean value, mean peak values and the area under the curve
of plasma glucose, insulin and C-peptide, compared to respective baseline values and placebo. Gastro-intestinal disturbances
were recorded in 67% of patients during therapy with acarbose.
Conclusion Acarbose has a positive therapeutic effect on glucose tolerance in cystic fibrosis patients, as shown by attenuation of postprandial
plasma glucose increase and a significant decrease in insulin secretion response. However, acarbose treatment was associated
with adverse gastro-intestinal effects that may prevent patients from accepting long-term therapy.
Received: 1 December 1997 / Accepted in revised form: 15 September 1998 |
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Keywords: | Cystic fibrosis Diabetes mellitus Impaired glucose tolerance Acarbose |
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