Circulating immune complexes and activation of the complement sequence in acute allergic bronchopulmonary aspergillosis |
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| Authors: | Raif S. Geha |
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| Affiliation: | 1. From the Department of Pediatrics, American University of Beirut Boston, Mass., USA;2. From the Department of Pediatrics, Harvard Medical School, Boston, Mass., USA;3. From the Divisions of Allergy and Immunology, Department of Medicine, Children''s Hospital Medical Center Boston, Mass., USA |
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| Abstract: | A 13-yr-old asthmatic girl with allergic bronchopulmonary aspergillosis (ABPA) exhibited eosinophilia, IgE hypergammaglobulinemia, serum precipitins to Aspergillus, a dual skin reaction to Aspergillus fumigatus, and positive, lymphocyte transformation in vitro in response to stimulation with Aspergillus fumigatus antigen. The acute phase of the disease was characterized by an increase in blood eosinophilia, a rise in serum IgE, circulating immune complexes, and evidence of activation of the complement system through the classical pathway. |
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| Keywords: | Reprint requests to: Raif S. Geha M.D. Allergy Division Children's Hospital Medical Center 300 Longwood Ave. Boston Mass. 02115. |
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