Hand-foot-uterus- (HFU) syndrome with hypospadias: The hand-foot-genital- (HFG) syndrome

Three brothers with the typical findings of the HFU-syndrome, but in addition with various degrees of hypospadias are reported. The family history otherwise was negative. The similarity of the pattern-profile of these cases with the mean pattern of the 11 previously reported ones is striking, as expressed by a product moment correlation of 0.83, 0.8 and 0.78 respectively. The widening of the concept of the HFU to that of a HFG-syndrome, as suggested by Poznanskiet al. in 1974, is discussed.Presented at the 12th annual meeting ESPR, Madrid, April 1975.