Relationship between preexposure to prey and PCPA-induced filicidal activity in Sprague-Dawley rats |
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Authors: | J H Copenhaver R L Schalock L Johnson T Stull T Pankratz |
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Affiliation: | Department of Psychiatry, University of Nebraska Medical Center, Omaha 68105. |
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Abstract: | Experiments, involving para-chloro-D,L-phenylalanine-induced pup-killing (filicide), were conducted to determine the effect of preexposure to the goal entity on the initial development and long-term expression of PCPA-induced filicide. Three groups of Sprague-Dawley rats (n = 50) were either preexposed/not preexposed, or preexposed for varying periods (5, 8, or 13 days) prior to receiving PCPA. Two major results were obtained: 1) preexposed animals were less filicidal than those not preexposed; and 2) there was an inverse relationship between the number of preexposures and filicide occurrence. The results are interpreted in reference to a serotonin-depletion habituation hypothesis. |
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